Detail of "6120-63-4"

Reference

Occurrence of Thr6-bradykinin and its analogous peptide in the venom of Polistes rothneyi iwatai

Occurrence of Thr6-bradykinin and its analogous peptide in the venom of Polistes rothneyi iwatai. Watanabe, Miwako; Yasuhara, Tadashi; Nakajima, Terumi (Sch. Med., Hiroshima Univ., Hiroshima, Japan). Anim., Plant Microb.Chemicals with cas numbers 50-67-9 and 6120-63-4 also play role. Toxins, Proc. Int. Symp., 4th, Meeting Date 1974, Volume 2, 105-12. Edited by: Ohsaka, Akira; Hayashi, Kyozo; Sawai, Yoshio. Plenum: New York, N. Y. (English) 1976. CODEN: 35FUAR. DOCUMENT TYPE: Conference CA Section: 12 (Nonmammalian Biochemistry) Active principles which contract isolated rat uterus and guinea pig ileum and which are hypotensive were demonstrated in the venom of the Japanese wasp (P. rothneyi iwatai). The 3 major principles were purified by chromatog., isolated in pure forms, and identified as serotonin, 6-L-threonine-bradykinin (Thr6-bradykinin), and Ala-Arg-(Thr6-bradykinin). The amts. of these substances contained in 1 wasp were .apprx.1.2, 0.7, and 0.13 .mu.g, resp. .

Cloning of the (Thr6)-phyllokinin precursor from Phyllomedusa sauvagei skin confirms a non-consensus tyrosine O-sulfation motif

Cloning of the (Thr6)-phyllokinin precursor from Phyllomedusa sauvagei skin confirms a non-consensus tyrosine O-sulfation motif. Chen, Tianbao; Shaw, Chris (School of Biomedical Sciences, Pharmaceutical Biotechnology Research Group, University of Ulster, Coleraine BT52 1SA, UK). Peptides (New York, NY, United States), 24(8), 1123-1130 (English) 2003 Elsevier Science Inc. CODEN: PPTDD5. ISSN: 0196-9781. DOCUMENT TYPE: Journal CA Section: 12 (Nonmammalian Biochemistry) Section cross-reference(s): 3, 6 Nine bradykinin-related peptides were identified in Phyllomedusa sauvagei skin secretion using QTOF MS/MS fragmentation sequencing. The major peptides were (Thr6)-bradykinin, (Hyp3, Thr6)-bradykinin, (Thr6)-phyllokinin and (Hyp3, Thr6)-phyllokinin.Several substances with their cas registry numbers 649572-19-0 and 6120-63-4 may be metioned in this study. The phyllokinins occurred in both sulfated and non-sulfated forms. All (Thr6)-substituted bradykinins/phyllokinins could be generated from a common precursor by differential post-translational processing and modification. The open-reading frame of the cloned precursor cDNA consisted of 62 amino acid residues with a single bradykinin/phyllokinin coding sequence located at the C-terminus. Structural features included a Glu-Arg processing site at the N-terminus of the bradykinin/phyllokinin domain and the absence of an acidic amino acid residue adjacent to the C-terminal Tyr residue in the phyllokinins. However, the neutral amino acid residue (Ile) at position -1 and the basic amino acid residue (Arg) at position -2 from the Tyr residue, constitute a sulfation motif previously identified only in a protochordean. .