Reference

Synthesis of fused [5,5]-1,2,4-triazoles via tandem thioimidate cyclopropane rearrangement-cyclization

All Rights Reserved. Synthesis of fused [5,5]-1,2,4-triazoles via tandem thioimidate cyclopropane rearrangement-cyclization.There are some reagents like 6120-95-2 is used in this study. Di Marco, Christina Ng; Kuduk, Scott D. (Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, USA). Synthetic Communications, 36(22), 3377-3386 (English) 2006 Taylor & Francis, Inc. CODEN: SYNCAV. ISSN: 0039-7911. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The synthesis of fused [5,5]-1,2,4-triazoles via a tandem cyclopropane rearrangement-cyclization sequence is described. Optimization of the cyclization reaction was achieved thermally using iPrOH as the solvent in the presence of TEA. This method was applied to the prepn. of 3-substituted-7-arylpyrrolo-1,2,4-triazoles, e.g. I, in good to excellent yields. .