Detail of "6127-17-9"

CAS Number:
6127-17-9
Name:
1H-Indole,6-chloro-2-methyl-
Molecular Structure:
Formula:
C₉H₈ClN
Molecular Weight:
165.6195
Synonyms:
Indole,6-chloro-2-methyl- (7CI,8CI);6-Chloro-2-methyl-1H-indole;6-Chloro-2-methylindole;NSC 115144;
Density:
1.273 g/cm³
Melting Point:
75-77°C
Boiling Point:
302.7 °C at 760 mmHg
Flash Point:
165.3 °C
Hazard Symbols:
Xi

Display：

6-Chloro-2-methylindole

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Studies on the metabolism of 5-hydroxytryptamine (serotonin): Studies on the metabolism of 5-hydroxytryptamine (serotonin). VII. Effects of haloindoles on cerebral 5-HT in various species.In this study， 1075-35-0 and 50-67-9 are also used. Sherman, Arnold D.; Gal, E. Martin (Dep. Psychiatry, Univ. Iowa, Iowa City, Iowa, USA). Psychopharmacol. Commun., 2(3), 285-93 (English) 1976. CODEN: PSCOD8. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 2 In a comparative study, the effect of intraventricularly or i.p. injected p-chloroamphetamine (I) [64-12-0] and some chloroindoles on cerebral levels of serotonin [50-67-9] was evaluated. 5-Chloroindole [17422-32-1] depressed serotonin levels in the brainstem and telencephalon for 3 days, 6-chloro-2-methylindole [6127-17-9] only during the 1st day. 5-Chloroindazole [698-26-0] had no effect at all. I was more toxic to guinea pigs than to rats. I and 5-chloro-2-methylindole [1075-35-0] had no effect on cerebral sertonin in chicks. Apparently, none of these compds. represented or was converted to a metabolite possibly responsible for the neurotoxic effects of I. .