Reference

Antibiotic drugs; sterile cefonicid sodium

Antibiotic drugs; sterile cefonicid sodium. (United States Food and Drug Administration, Rockville, MD 20857, USA). Fed. Regist., 49(170), 34347-50, (English) 30 Aug 1984. CODEN: FEREAC. ISSN: 0097-6326. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 Requirements for certification of sterile cefonicid Na (I Na) [61270-78-8] are established under the Federal Food, Drug, and Cosmetic Act. The content and identity tests for I Na involve high-performance liq. chromatog. on an octadecylsilane-bonded silica column with 0.2M ammonium phosphate-MeOH-H2O (1:2.5:16.5) and detection at 254 nm.

SK&F 75073, new parenteral broad-spectrum cephalosporin with high and prolonged serum levels

SK&F 75073, new parenteral broad-spectrum cephalosporin with high and prolonged serum levels. Actor, Paul; Uri, Joseph V.; Zajac, Ihor; Guarini, Joseph R.; Phillips, Lillian; Pitkin, Donald H.; Berges, David A.; Dunn, George L.; Hoover, John R. E.; et al. (Res. Dev. Div., Smith Kline and French Lab., Philadelphia, Pa., USA). Antimicrob. Agents Chemother., 13(5), 784-90 (English) 1978. CODEN: AMACCQ. ISSN: 0066-4804. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3 SK+F 75073 (I) [61270-78-8], a new parenteral cephalosproin, had broad in vitro and in vivo antibacterial activity even against isolates usually resistant to chepalothin and cefazolin. This activity induced indole-pos. Proteus and Enterobacter species and some Serratia isolates. Proteus mirabilis strains were particularly susceptible, as were Haemophilus influenzae and Neisseria species. The activity of I against gram-pos. bacteria was poorer than that of the control cephalosporins. I was highly bound to serum proteins, and a loss in in vitro activity was obsd. in the presence of serum. Parenteral administration of I to expt. animals (mice, dogs, squirrel monkeys) resulted in high and prolonged serum levels when compared with cefazolin and other injectable cephalosporins. This favorable serum profile was reflected in the excellent protection obsd. in mice infected with pathogenic bacteria.