Detail of "61278-38-4"

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Biosynthesis of a disialylated sequence in N-linked oligosaccharides: identification of an N-acetylglucosaminide (a2 ? 6)-sialyltransferase in Golgi apparatus from rat liver

Biosynthesis of a disialylated sequence in N-linked oligosaccharides: identification of an N-acetylglucosaminide (a2 ? 6)-sialyltransferase in Golgi apparatus from rat liver. Paulson, James C.; Weinstein, Jasminder; De Souza-E-Silva, Ursula (Sch. Med., Univ. California, Los Angeles, CA 90024, USA). Eur. J. Biochem., 140(3), 523-30 (English) 1984. CODEN: EJBCAI. ISSN: 0014-2956. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) Rat liver Golgi app. contained a CMP-N-acetylneuraminate-N-acetylglucosaminide (a2?6)-sialyltransferase (I), which catalyzes the conversion of the human milk oligosaccharide LS-tetrasaccharide-a (NeuAca2?3Galb1?3GlcNAcb1?3Galb1?4Glc) to disialyllacto-N-tetraose contg. disialylated terminal sequence found in N-linked oligosaccharides of glycoproteins. I exhibited a marked preference for the sequence, NeuAca2?3-Galb1?3GlcNAc, as an acceptor substrate. Thus, the order of addn.In this experiment, several chemicals are used like 61278-38-4 and 83745-05-5 of the 2 sialic acids in the disialylated terminal sequence is proposed to be 1st the terminal sialic acid in the NeuAca2?3Gal linkage followed by the internal sialic acid in the NeuAca2?6GlcNAc linkage. Sialylation in vitro of the type 1 branches (Galb1?3GlcNAc-) of the N-linked oligosaccharides of asialo-prothrombin to produce the same disialylated sequence was also demonstrated. .