Detail of "61281-38-7"

CAS Number:
61281-38-7
Name:
Schisandrin A
Molecular Structure:
Formula:
C₂₄H₃₂O₆
Molecular Weight:
416.51
Synonyms:
Dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer;(+)-Deoxyschizandrin;Deoxyschisandrin;Deoxyschizandrin;Schizandrin A;Wuweizisu A;
Density:
1.08 g/cm³
Boiling Point:
544.2 °C at 760 mmHg
Flash Point:
215.6 °C

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Correlation between phylogeny, chemical constituents and pharmaceutical aspects of plants and applications in drug research: Correlation between phylogeny, chemical constituents and pharmaceutical aspects of plants and applications in drug research. Part I. (Chinese Academy of Medical Sciences; Lab. Med. Plants, Inst. Mater. Med., Peking, Peop. R. China). Chih Wu Hsueh Pao, 19(3), 172-81 (Chinese) 1977. CODEN: CHWHAY. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 11, 25, 26, 28 The pharmacol. properties and chem. constituents of 9 Artemisia, 14 Salvia, 8 Schizandra, 9 Dioscorea, 9 Paeonia and 6 Pueraria species were investigated and their clin. application explored. E.g., Salvia contg. tanshinones and cryptotanshinone [35825-57-1] are antimicrobial, Schizandra contg. wuweizisu C [61301-33-5], g-schizandrin [61281-37-6], wuweizichun B [61281-39-8], schizandrin [552-66-9] and deoxyschizandrin [61281-38-7] show blood serum transaminase-lowering activity, and Pueraria contg. daidzein [486-66-8], daidzin [552-66-9], and puerarin [3681-99-0] are capable of stimulating blood circulation.

Studies on the transaminase-lowering principles of Schisandra sphenanthera Rehd et Wils: Studies on the transaminase-lowering principles of Schisandra sphenanthera Rehd et Wils. (Shanghai Institute of Materia Medica, Shanghai, Peop. R. China). Sheng Wu Hua Hsueh Yu Sheng Wu Wu Li Hsueh Pao, 8(4), 333-40 (Chinese) 1976. CODEN: SHWPAU. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Schisantherin A (I) [58546-56-8], B [58546-55-7], C [64938-51-8], D [64917-82-4] and E [64917-83-5] and deoxyschisandrin [61281-38-7] were isolated from S. sphenanthera, a Chinese herb medicine for treatment of virus-induced hepatitis. A, B, C an D decreased the serum level of glutamic-pyruvic transaminase [9000-86-6] in exptl. animals and human subjects with h epatitis, whereas E and deoxyschisandrin had no effect. Intragastric application of I (100 mg/kg) for 3-4 doses protected CCl4 [56-23-5]-induced liver damage in mice as examd. by electron microscopy. I-3H was readily metabolized and excreted in urine of mice following oral administration. Immunochem. tests revealed that the lowered blood transaminase activity was due to an inhibition of the enzyme activity in liver by I.