Detail of "613-97-8"

Reference

The metabolism of 4-substituted N-ethyl-N-methylanilines

The metabolism of 4-substituted N-ethyl-N-methylanilines. III. Effect of various potential inhibitors, activators and inducers on a-C- and N-oxidation. Gorrod, J. W.; Patterson, L. H. (Dep. Pharm., Chelsea Coll., London SW3 6LX, UK). Xenobiotica, 13(9), 521-9 (English) 1983. CODEN: XENOBH. ISSN: 0049-8254. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The a-C-oxidn. of N-ethyl-N-methylaniline (I) [613-97-8] and of the 4-chloro (II) [35113-87-2] and 4-methyl (III) [13519-85-2] derivs. was inhibited by SKF 525A, 2,4-dichloro-6-phenylphenoxyethylamine (DPEA), CO and cyanide and induced by phenobarbitone but not by 3-methylcholanthrene pretreatment. The N-oxidn. of these tertiary anilines was not influenced by SKF-525A, CO, or cyanide, nor by phenobarbitone or 3-methylcholanthrene pretreatment. The N-oxidn. was activated by DPEA and n-octylamine and inhibited by 1-naphthylthiourea. Thus, metabolic a-C-oxidn. of these substrates may be mediated by a cytochrome P 450-dependent pathway whereas N-oxidn. may be mediated by a flavoprotein amine oxidase.

Site of alkylation of N-methyl- and N-ethylaniline in the gas phase: A tandem mass spectrometric study

Site of alkylation of N-methyl- and N-ethylaniline in the gas phase: A tandem mass spectrometric study. Ackloo, Suzanne; Harrison, Alex G.; Terlouw, Johan K. (Department of Chemistry, McMaster University, Hamilton, ON L8S 4M1, Can.). Journal of Mass Spectrometry, 39(6), 647-654 (English) 2004 John Wiley & Sons Ltd. CODEN: JMSPFJ. ISSN: 1076-5174. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) N-Methylaniline (NMA) was ethylated and N-ethylaniline (NEA) was methylated under chem. ionization conditions using C2H5I and CH3I, resp., as reagent gases. The structures of the resulting m/z 136 adduct ions have been probed using metastable ion and collision-induced dissocn. (CID) methods. From the similarity of the spectra obtained and from the presence of structure-diagnostic ions at m/z 59 (CH3NHC2H5+·) and m/z 44 (CH3NHCH2+), it is concluded that predominantly N-alkylation occurs in both systems. This interpretation was aided by the use of C2D5I and CD3I as reagents. Adduct ions of m/z 136 were also formed by ethylation of the isomeric toluidines and by methylation of the ring-ethylanilines. 613-97-8 and 589-16-2 which are cas registry numbers of chemicals are mentioned. The resulting CID mass spectra were distinctly different from those obtained for the m/z 136 ions obtained by alkylation of NMA and NEA. Protonation of N-ethyl-N-methylaniline using CH3C(=O)CH3 as Bronsted acid reagent produced an m/z 136 species whose CID mass spectrum also featured intense ion signals at m/z 59 and 44. This observation led to the conclusion that protonation with acetone as reagent results, in this case, in dominant N-protonation. However, the CID mass spectrum of the m/z 136 ion formed when CH3OH was the protonating agent featured a weak signal at m/z 44 and no signal at m/z 59. Hence it was concluded that the latter m/z 136 ion contains a larger contribution from the ring-protonated adduct. .