Detail of "6130-64-9"

Reference

Effect of benzylpenicillin in mice infected with endotoxin-liberating or non-liberating variant strains of Neisseria meningitidis

Effect of benzylpenicillin in mice infected with endotoxin-liberating or non-liberating variant strains of Neisseria meningitidis. Andersen, Bjoerg Marit; Solberg, Otto (Dep. Infect. Dis. Intern. Med., Ullevaal Hosp., Oslo, Norway). Scand. J. Infect. Dis., 16(3), 257-66 (English) 1984. CODEN: SJIDB7. ISSN: 0036-5548. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of benzylpenicillin [61-33-6] treatment was studied in mice infected i.p. with endotoxin-liberating (E+) and nonliberating (E-) meningococci derived from the same original serogroup B strain. The E+ meningococci were significantly more virulent to mice than the E- variants in untreated animals. Large doses of benzylpenicillin given i.v. immediately after i.p. inoculation of E+ or E- meningococci resulted in complete, or almost complete, survival. When treatment started later the no. of surviving E- infected animals increased in all treatment regimens. By contrast, E+ infected animals had one or more treatment groups in all regimens that did not respond to benzylpenicillin at all. Benzylpenicillin treatment was given over a period of time as intermittent, regular i.v. doses, or as a depot prepn. (benzylpenicillin procaine [6130-64-9]). The mortality obsd. in E+ infected mice after benzylpenicillin i.v. was 75%, after benzylpenicillin procaine s.c. 82.5%, while animals receiving only saline i.v. had a mortality of 67.5%. The corresponding mortalities for E- infected animals were 15%, 42.5%, and 42.5%, resp.

Stabilization of suspensions

Stabilization of suspensions. Huettenrauch, Reinhard (VEB Jenapharm, Ger. Dem. Rep.). Ger. (East) DD 209970 A1 30 May 1984, 8 pp. (German). (German Democratic Republic). CODEN: GEXXA8. CLASS: IC: A61K009-10; B01F017-00; B01F003-00. APPLICATION: DD 82-242684 23 Aug 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The stability of pharmaceutical suspensions, esp. for parenteral administration, is improved by the addn of sugars or hexitols, esp. sucrose [57-50-1], fructose [57-48-7], or sorbitol [50-70-4]. Thus, 300 g micronized procaine benzylpenicillin [6130-64-9], 70 g Na benzylpenicillin [69-57-8], and 90 g fructose were mixed and dissolved in 1L H2O for injection under aseptic conditions. After slight shaking the suspension is suitable for i.m. injection.