Detail of "61318-91-0"

Reference

Studies on the antifungal activities of sulconazole nitrate

Studies on the antifungal activities of sulconazole nitrate. III. Therapeutic effect on experimental Trichophyton mentagrophytes infection. Iwata, Kazuo; Yamamoto, Yoshimasa (Dep. Microbiol., Meiji Coll. Pharm., Japan). Shinkin to Shinkinsho, 25(2), 158-62 (Japanese) 1984. CODEN: SHSHBL. ISSN: 0583-0516. DOCUMENT TYPE: Journal CA Section: 10 (Microbial Biochemistry) The consecutive topical administration of 1% or 2% sulconazole nitrate [61318-91-0] suspended in polyethylene glycol for 2 wk resulted in a marked therapeutic effect on cutaneous infection of guinea pigs with a T. mentagrophytes strain in terms of improvement of lesions and of neg. culture of inoculated organism, to a degree equiv. to clotrimazole.

Pharmacokinetics of sulconazole nitrate (1)

Pharmacokinetics of sulconazole nitrate (1). Fate in rats after application to the skin. Fujihara, Michio; Hirakoso, Kazuyuki; Harigaya, Shoichi (Biol. Res. Lab., Tanabe Seiyaku Co., Ltd., Saitama 335, Japan). Oyo Yakuri, 28(1), 145-54 (Japanese) 1984. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Absorption, distribution, and excretion of sulconazole nitrate (SCZ)(I) [61318-91-0] were studied with rats following application of 1%-14C-SCZ cream to their intact and damaged skin for 24 h. In intact skin rats, the radioactivity in blood and plasma was very low throughout the exptl. period and detectable only at 24 h. In rats with damaged skin, however, the max. radioactivity was reached at 6 h, thereafter declined gradually, and was below the detecting limit (0.030 mg/mL) 72 h after application. The levels of radioactivity in various tissues and organs in rats with intact skin were increased slowly after application and reached a peak level at 24 h. In rats with damaged skin, the max. levels in most tissues and organs were 3 to 5 times higher than those with intact skin. The half-lives of radioactivity in the local stratum corneum of the intact skin and in the vicinity of the damaged skin were ~30 and 22 h, resp. In rats with intact and damaged skin, the radioactivity (detd. by the combustion method) was high in the applied skin site, moderate in the adrenal, liver, kidney, and lung, and very low in the spleen, brain, blood, and muscle. The autoradiog. data was in good agreement with the above combustion data. Within 7 days after application, the resp. recovery of radioactivity in the urine and feces was 2.0 and 4.1% of the dose in rats with the intact skin, and 4.1 and 10.2% in those with the damaged skin. These results indicated that the rates of radioactivity absorbed from intact skin and damaged skin were about 6 and 14%, resp.