CAS No.61337-67-5,Mirtazapine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	61337-67-5
Name:	Mirtazapine
Article Data:	40

Formula:	C₁₇H₁₉N₃
Molecular Weight:	265.358
Synonyms:	Mirtabene;2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;
EINECS:	288-060-6
Density:	1.22 g/cm³
Melting Point:	114-116 °C
Boiling Point:	432.4 °C at 760 mmHg
Flash Point:	215.3 °C
Solubility:	DMSO: 8 mg/mL
Appearance:	white crystalline solid
Hazard Symbols:	F,T
Risk Codes:	11-23/24/25-39/23/24/25
Safety:	22-24/25
PSA:	19.37000
LogP:	2.48180

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Chemistry

IUPAC Name: (±)-1,2,3,4,10,14B-Hexahydro-2-[11C]methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine
Molecular Formula: C₁₇H₁₉N₃
Molecular Weight: 265.35 g/mol
Canonical SMILES: N12[C@@H](c3c(cccc3)Cc3c1nccc3)C[N@@](C)CC2
InChI: InChI=1/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Serotonin
Classification Code: Adrenergic Agents; Adrenergic Antagonists; Adrenergic alpha-antagonists; Antidepressant; Antidepressive Agents; Antidepressive agents, tricyclic; Central Nervous System Agents; Histamine Agents; Histamine Antagonists; Histamine H1 antagonists; Neurotransmitter Agents; Psychotropic Drugs
Melting Point: 114-116 °C
solubility DMSO: 8 mg/mL, soluble
Index of Refraction: 1.667
Molar Refractivity: 80.68 cm³
Molar Volume: 216.5 cm³
Polarizability: 31.98×10^-24 cm³
Surface Tension: 59.4 dyne/cm
Density: 1.22 g/cm³
Flash Point: 215.3 °C
Enthalpy of Vaporization: 68.82 kJ/mol
Boiling Point: 432.4 °C at 760 mmHg
Vapour Pressure of Mirtazapine (CAS NO.61337-67-5): 1.11E-07 mmHg at 25 °C

History

Mirtazapine was introduced by Organon International in the United States in 1990 for the treatment of depression. It quickly spread throughout most of the rest of the world as well and became a widely used antidepressant, particularly for those desiring to gain weight.

Uses

Mirtazapine (CAS NO.61337-67-5) is a tetracyclic antidepressant (TeCA) used primarily in the treatment of depression. It is also sometimes used as an anxiolytic, hypnotic, antiemetic, appetite stimulant, and antihistamine, among other indications. Along with its close analogues mianserin and setiptiline, mirtazapine is one of the few noradrenergic and specific serotonergic antidepressants (NaSSAs).

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	1071ug/kg/I (1.071mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Journal of Clinical Psychiatry. Vol. 59, Pg. 233, 1998.

Safety Profile

Human systemic effects. When heated to decomposition it emits toxic vapors of NO_x.
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany of Mirtazapine (CAS NO.61337-67-5): 3

Specification

Mirtazapine (CAS NO.61337-67-5), its Synonyms are 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine ; Mirtazapina ; Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl- ; Remeron ; Remeron SolTab . It is white crystalline solid.