Reference

Synthesis of antidepressant-mirtazapine

All Rights Reserved. Synthesis of antidepressant-mirtazapine. Zhang, Tao; Wu, Fan-hong (School of Chemistry and Pharmaceutics, East China University of Science and Technology, Shanghai 200237, Peop. Rep. China). Huadong Ligong Daxue Xuebao, Ziran Kexueban, 32(3), 318-320, 326 (Chinese) 2006 Huadong Ligong Daxue Xuebao Bianjibu. CODEN: HLIXEV. ISSN: 1006-3080. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Mirtazapine [i.e., 1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benza zepine] was prepd. by a seven-step reaction, namely nucleophilic ring-opening reaction, chlorination, cyclization, nucleophilic substitution, hydrolysis, redn. 61337-89-1 and 109-83-1 which are cas registry numbers of chemicals are mentioned. and cyclization from styrene oxide and N-methylethanolamine as the starting materials, with overall yield of 22. 6%. The structure of mirtazpine was confirmed by 1H-NMR (H1-NMR) and MS(mass spectrum), and the purity was 99.79% by HPLC. .