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Detail of "614-39-1"

  • MSDS Download
  • CAS Number:
  • 614-39-1
  • Name:

  • Benzamide,4-amino-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1)

  • Superlist Name:
  • Procainamide hydrochloride
  • Molecular Structure:
  • Formula:
  • C13H22ClN3O
  • Molecular Weight:
  • 271.83
  • Synonyms:
  • Procamid;Procamide;Procan SR;Procapan;Procardyl;Pronestyl;Pronestyl hydrochloride;Spicain amide;Benzamide,4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride (9CI);Benzamide, p-amino-N-[2-(diethylamino)ethyl]-,monohydrochloride (8CI);4-Amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride;Amidoprocaine;Amisalin;Cardiorytmin;HC 5006;Novocaineamide hydrochloride;Novocamid hydrochloride;Procainamidemonohydrochloride;
  • EINECS:
  • 210-381-7
  • Melting Point:
  • 165-168 °C
  • Boiling Point:
  • 421.8 °C at 760 mmHg
  • Flash Point:
  • 208.9 °C
  • Solubility:
  • soluble in water
  • Appearance:
  • White to slightly yellow powder
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 22-36/37/38
  • Safety:
  • 26-36-37/39 Details
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CAS No.614-39-1 Procainamide hydrochloride

Procaine Hydrochloride

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CAS No.614-39-1 Procainamide hydrochloride

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614-39-1

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Procainamidi Hydrochloridum

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Procainamide Hydrochloride, USP

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Procainamide HCl

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Reference

Lung pH pulmonary absorption of nonvolatile drugs in the rat
Lung pH pulmonary absorption of nonvolatile drugs in the rat. Schanker, Lewis S.; Less, Michael J. (Dep. Pharmacol., Univ. Missouri, Kansas City, Mo., USA). Drug Metab. Dispos., 5(2), 174-8 (English) 1977. CODEN: DMDSAI. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effect of pH on pulmonary absorption of nonvolatile drugs was investigated in the rat. Krebs-Ringer phosphate solns. (pH 6.2 and 7.4), Krebs-Ringer pyrophosphate soln. (pH 8.4), or an unbuffered salt soln. contg. a drug were administered through tight-fitting tracheal cannulas to anesthetized animals. After 3 min, the lungs were removed and assayed for the amt. of drug that remained. Weak acids and a weak base were absorbed most rapidly at pH values at which the drugs were least ionized. For example, with the base procainamide-HCl [614-39-1], 36% of the dose was absorbed at pH 6.2 and 76% at pH 8.4. With the acid sulfisoxazole [127-69-5], 71% was absorbed at pH 6.2 and 55% at pH 8.4. Similarly, with p-aminosalicylic acid [65-49-6], 77% was absorbed at pH 6.2 and 40% at pH 8.4. In contrast to these results, compds. such as urea [57-13-6] and amitrole [61-82-5], which remain completely nonionized over the pH range studied, showed no change in absorption rate when the pH was varied. The 2 weak acids and the weak base were absorbed from an unbuffered soln. as though the pH at the site of drug absorption was between 6.2 and 7.4. The absorption rate for each weak electrolyte from unbuffered soln., when compared graphically with the respective absorption rates from buffered solns., indicated that the pH at the site of drug absorption is .apprx.6.6.
Absorption kinetics of procainamide in humans
Absorption kinetics of procainamide in humans. Manion, Carl V.; Lalka, David; Baer, Denise T.; Meyer, Melvin B. (Res. Lab., Astra Pharm. Prod., Inc., Framingham, Mass., USA). J. Pharm. Sci., 66(7), 981-4 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Plasma procainamide (I) [51-06-9] concns. following administration of 500 mg of I-HCl [614-39-1] by i.v. infusion, conventional capsules, and sustained-release tablets were compared in healthy male volunteers. Two-compartment open modeling of the plasma levels from the i.v. infusion expts. yielded mean Kel, k12, and k21 values of 0.0162, 0.0542, and 0.0233 min-1, resp. The bioavailability of the oral prepns. (versus i.v.) averaged 83% for the capsule and 79% for the sustained-release tablet. Calcns. using a previously reported method suggested that absorption was a 1st order process with mean ka's of 0.0336 and 0.0039 min-1 for the capsule and sustained-release tablet, resp. The sustained-release formulation exhibited delayed release and adequate bioavailability.
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