Reference

Studies on sulfhemoglobin formation by various drugs

Studies on sulfhemoglobin formation by various drugs. 2. Nomura, Akira (Dep. Pharmacol., Gifu Univ. Sch. Med., Gifu, Japan). Nippon Yakurigaku Zasshi, 73(4), 423-35 (Japanese) 1977. CODEN: NYKZAU. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) SulfHb (SHb) and metHb(MHb) formation stimulation by various aniline derivs. was examd. in mice. With a single i.p. administration, metHb formation was induced by aniline-HCl [142-04-1], 2-methylaniline-HCl [636-21-5], 3-methylaniline-HCl [638-03-9], 4-methylaniline-HCl [540-23-8], 3-trifluoromethylaniline (3-TFMA) [98-16-8], 4-trifluoromethylaniline (4-TFMA) [455-14-1], 2,3-dichloroaniline [608-27-5], 2-aminophenol-HCl [51-19-4], acetanilide (AA) [103-84-4], 2-hydroxyacetanilide [614-80-2], N-methylaniline (NMA) [100-61-8], N,N-dimethylaniline (NDMA) [121-69-7], N-ethylaniline-HCl (NEA) [4348-19-0], and N,N-diethylaniline [91-66-7]. Sulfhemoglobinemia, which appeared much later than stimulation of MHb formation with a single dose of the aniline derivs., was induced by 3-TFMA, 4-TFMA and NMA. After three consecutive doses, sulfhemoglobinemia was induced by AA, 3-hydroxyacetanilide [621-42-1], NDMA and NEA, even though SHb was not demonstrated after a single dose. Structure-activity relationships for the SHb and MHb formation-inducing properties of the aniline derivs. was discussed.

Effect of intermediate products of synthesis and some potential metabolites of heptacaine chloride on mammalian chromosomes

Effect of intermediate products of synthesis and some potential metabolites of heptacaine chloride on mammalian chromosomes. Karasova, Milada; Catar, Gustav; Kieferova, L'ubica; Cizmarik, Jozef (Univ. Komenskeho, Bratislava, Czech.). Bratisl. Lek. Listy, 82(6), 1423-9 (Slovak) 1984. CODEN: BLLIAX. ISSN: 0006-9248. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Cytogenetic anal. of the bone marrow cells of Chinese hamsters was used to test the intermediate products of the synthesis of heptacaine chloride [55792-21-7] and some of its potential metabolites: 2-aminophenol [95-55-6], 2-acetaminophenol [614-80-2], 2-heptyloxyacetanilide [55792-58-0], heptacaine N-oxide (I) [77463-82-2], 2-heptyloxyaniline hydrochloride [66642-15-7], and piperidine ethyl alc. [3040-44-6]. All the substances failed to induce chromosomal aberrations in the the bone marrow cells.