Detail of "614-96-0"

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CAS Number:
614-96-0
Name:
5-Methylindole
Molecular Structure:
Formula:
C₉H₉N
Molecular Weight:
131.17
Synonyms:
1H-Indole, 5-methyl- (9CI);Indole, 5-methyl- (8CI);1H-Indole, 5-methyl-;Indole, 5-methyl-;5-methyl-1H-indole;5-Methylindol;
EINECS:
210-400-9
Density:
1.11 g/cm³
Melting Point:
60-62 °C(lit.)
Boiling Point:
269 °C at 760 mmHg
Flash Point:
114.7 °C
Solubility:
60-62 °C(lit.)
Appearance:
white to slightly beige crystalline solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36-24/25 Details

Effects of simple indoles, noradrenaline, nicotine, and tyramine on action potential and contractility of the isolated guinea-pig papillary muscle: Effects of simple indoles, noradrenaline, nicotine, and tyramine on action potential and contractility of the isolated guinea-pig papillary muscle. Brasch, H.; Iven, H.; Zetler, G. (Abt. Pharmakol., Med. Hochsch. Luebeck, Luebeck, Ger.). Naunyn-Schmiedeberg's Arch. Pharmacol., 299(3), 259-65 (English) 1977. CODEN: NSAPCC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 Simultaneous recordings of both the transmembrane action potential and the contractions were made in isolated elec. driven papillary muscles of guinea pig in order to compare the effects of 6-methoxyindole (I) [3189-13-7], 3-methylindole (3-MI) [83-34-1] and 5-methylindole (5-MI) [614-96-0] with those of (-)-noradrenaline [51-41-2], nicotine hydrogen l-tartrate [3845-12-3], and tyramine-HCl [60-19-5]. Noradrenaline, nicotine, tyramine, and I enhanced the contractility, while 3-MI and 5-MI had only irregular effects. The active compds. shortened the time-to-peak tension and increased the rate of relaxation. The duration of the action potential was prolonged by noradrenaline, nicotine, and tyramine, but shortened by 3-MI, 5-MI, and I.

Separation of indoles: Separation of indoles. (Asahi Chemical Industry Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59164775 A2 17 Sep 1984 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D209-04; C07D209-06. APPLICATION: JP 83-39180 11 Mar 1983. DOCUMENT TYPE: Patent CA Section: 45 (Industrial Organic Chemicals, Leather, Fats, and Waxes) Section cross-reference(s): 27 Org. mixts. contg. indoles are chromatographed with MeCN and/or EtCN on zeolites having ~6-? or larger openings and substituted mainly with Ag ions, giving indoles which are sepd. by distn. Thus, 144 g of a mixt. of indole (I) [120-72-9] 4.0, naphthalene 9.1, 1-methylnaphthalene 21.9, 2-methylnaphthalene 40.0, biphenyl 9.1, dimethylnaphthalene 15.4, and 5-methylindole (II) [614-96-0] 0.5% was chromatographed with MeCN in a column contg. 360 g AgNO3-treated zeolite at 86° to recover 95% indoles contg. 92.7% I and 7.3% II and distd. in a column having 35 theor. plates at reflux ratio 8 to give I having purity 99.9%.