Reference

Antitumor effects of 1-hexylcarbamoyl-5-fluorouracil in combination with other antitumor agents on sarcoma 180-bearing mice

Antitumor effects of 1-hexylcarbamoyl-5-fluorouracil in combination with other antitumor agents on sarcoma 180-bearing mice. Sasaki, Kenichi; Furusawa, Shinobu; Takayanagi, Giichi (Cancer Res. Inst., Tohoku Coll. Pharm. Sci.Some commonly used reagents like 50-07-7 and 17902-23-7 are used in this experiment., Sendai 983, Japan). Oyo Yakuri, 26(2), 233-8 (English) 1983. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The antitumor action of 1-hexylcarbamoyl-5-fluorouracil (HCFU) [61422-45-5], against the solid form of Sarcoma 180 in mice was studied in combination with various antitumor agents such as doxorubicin (DOX) [23214-92-8], bleomycin (BLM) [11056-06-7], mitomycin C (MMC) [50-07-7], 6-mercaptopurine (6-MP) [50-44-2], 6-mercaptopurine riboside [574-25-4], cyclophosphamide (CPA) [50-18-0], and cisplatin [15663-27-1], and the results were compared with those obtained through the administration of 5-FU [51-21-8] and tegafur [17902-23-7] alone. HCFU (50 mg/kg/day for 3 days) gave nearly the same degree of antitumor effect as 5-FU (20 mg/kg/day for 3 days) and tegafur (100 mg/kg/day for 3 days). The combination of HCFU, 5-FU, or tegafur with DOX, BLM, MMC, 6-MP, 6-MPR, CPA, or cisplatin enhanced the antitumor effects. On the other hand, the antitumor activity of HCFU was enhanced by the coadministration of thymine [65-71-4] or uracil [66-22-8] without enhancement of toxicity. However, the activity of HCFU was not enhanced by the coadministration of cytosine [71-30-7] or uridine [58-96-8]. .

Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs

Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs. Okeda, R.; Karakama, T.; Kimura, S.; Toizumi, S.; Mitsushima, T.; Yokoyama, Y. (Med. Res. Inst., Tokyo Med. and Dent. Univ., Tokyo, Japan). Acta Neuropathol., 63(4), 334-43 (English) 1984. CODEN: ANPTAL. ISSN: 0001-6322. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) 5-Fluorouracil [51-21-8] and its masked compds. tegafur [17902-23-7] and carmofur [61422-45-5] were administered orally to dogs daily for 6 mo, and their chronic neurotoxic effects were examd. morphol. The results indicated that all 3 compds. produce changes morphol. identical with one another in respect to the site of their manifestation and nature of lesion, that their common degraded product a-fluoro-b-alanine [3821-81-6] plays a crucial role in their neurotoxic actions, and that vacuolar lesions, to which myelin was more vulnerable than neurons, can develop where the toxic substance readily deposits and accumulates.