Reference

Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base

Nakagawa, Hidehiko; Ohyama, Ryo; Kimata, Ayako; Suzuki, Takayoshi; Miyata, Naoki (Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467-8603, Japan).Several substances are used for example 6148-64-7 and 29211-49-2 which are their cas registry numbers. Bioorganic & Medicinal Chemistry Letters, 16(23), 5939-5942 (English) 2006 Elsevier Ltd. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Pyrazolones such as I are prepd. as analogs of edaravone; the oxidn. potentials of the pyrazolones are detd. as well as the hydroxyl radical scavenging activities for some of the compds. I is more effective in a hydroxyl radical scavenging assay than edaravone, with an IC50 value of 0.018 mM as compared to edavarone's IC50 value of 0.25 mM. The hydroxyl radical scavenging activities of some of the pyrazolones are correlated to their oxidn. potentials. The energies of protonation and the calcd. pKa values are detd. by calcns. for selected pyrazolones. .