615-05-4

Reference

Mutagenicity of structurally related aromatic amines in the Salmonella/mammalian microsome test with various S-9 fractions

Mutagenicity of structurally related aromatic amines in the Salmonella/mammalian microsome test with various S-9 fractions. Shahin, M. M.; Chopy, C.; Mayet, M. J.; Lequesne, N. (L'Oreal Res. Lab., L'Oreal, Aulnay-sous-Bois, Fr.). Food Chem. Toxicol., 21(5), 615-19 (English) 1983. CODEN: FCTOD7.There are some reagents with their cas registry numbers 37878-54-9 and 30616-96-7 are used in this study. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The related monocyclic arom. amines 2,4-diaminoanisole (DAA) [615-05-4], 2,4-diaminopropoxybenzene (DAPB) [37878-54-9], and 2,4-diaminobutoxybenzene (DABB) [30616-96-7] were tested for mutagenic activity in S. typhimurium strain TA 1538, using S-9 fractions from liver, kidney, and spleen of male rats for metabolic activation. In the presence of an uninduced liver S-9 fraction, DAA was weakly mutagenic (a 2- or 3-fold increase), and the other compds. were neg. Uninduced S-9 prepns. from kidney, spleen or a mixt. of kidney, spleen, and liver homogenates did not activate any of the compds. On the other hand, S-9 fractions from rat liver induced with Aroclor 1254 or with a combination of phenobarbital and 5,6-benzoflavone activated both DAA and DAPB, DAA being by far the more mutagenic of the 2. S-9 prepns. from mixed, liver, kidney, and spleen homogenates from animals pretreated with Aroclor or phenobarbital and 5,6-benzoflavone were less effective than the liver homogenates. Aroclor-induced S-9 fractions from kidneys slightly activated DAA, but S-9 fractions from spleen were ineffective in all cases. The mutagenicity ranking of the arom. amines was DAA > DAPB > DABB. The latter compd. caused little or no increase over the control nos. of revertant colonies. The order of effectiveness of inducers was Aroclor 1254 > phenobarbital + 5,6-benzoflavone > no inducer, and that of prepns. from different organs was liver > mixt. of liver, kidney and spleen > kidney > spleen. .

Hexachlorobenzene induction of 2,4-diaminoanisole mutagenicity in vitro

Hexachlorobenzene induction of 2,4-diaminoanisole mutagenicity in vitro. Dybing, Erik; Aune, Tore (Dep. Environ. Toxicol., Natl. Inst. Public Health, Oslo, Norway). Acta Pharmacol. Toxicol., 40(5), 575-83 (English) 1977. CODEN: APTOA6. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 3 I.p. administration of 10 and 50 mg/kg hexachlorobenzene (HCB) [118-74-1] increased rat liver microsomal activation of 2,4-diaminoanisol (I) [615-05-4] to a mutagen and increased liver ethylmorphine N-demethylase [9032-78-4], resp. I mutagenicity was increased 24 h after HCB-pretreatment, whereas ethylmorphine N-demethylase 1st increased after 48 h. A sex difference in the inducing effects of HCB on ethylmorphine N-demethylase, but not on I mutagenicity was obsd. HCB-pretreatment also increased I mutagenicity in the kidneys, but not in the lungs or in fetal liver.