Detail of "6153-92-0"

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Regio-related differential induction of hepatic microsomal heme oxygenase and cytochrome P450 by substituted imidazole and pyridine compounds in rats

Regio-related differential induction of hepatic microsomal heme oxygenase and cytochrome P450 by substituted imidazole and pyridine compounds in rats. Kobayashi, Yasuna; Yamamoto, Toshinori; Okui, Eiichi; Kotani, Eiichi; Yoshida, Takemi; Kuroiwa, Yukio (Sch. Pharm. Sci., Showa Univ., Tokyo 142, Japan). Japanese Journal of Toxicology and Environmental Health, 42(6), 468-478 (English) 1996 Pharmaceutical Society of Japan. CODEN: JJTHEC. ISSN: 0013-273X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of variously substituted pyridine and imidazole compds. and some of their chlorinated derivs. on the induction of hepatic microsomal heme oxygenase (HO) and cytochrome P 450 (P 450) were investigated in rats. 2-Benzylpyridine was able to induce HO to about 4.4-fold the control levels. 6153-92-0 which is the cas registry number is also used here. 3-Benzylpyridine also increased HO to a lesser extent, but 4-benzylpyridine did not. Benzoylpyridines, phenylpyridines, and diphenylmethylpyridines also produced a similar regio-differential induction of HO to benzylpyridines. Of the pyridine compds. examd., 2-phenylpyridine was the most potent inducer of HO. These substituted pyridines also increased the hepatic P 450 content by inversely relating to the magnitudes of their abilities to induce HO. These results indicate that the substituted pyridines which have some lipophilic moieties, such as phenyl-, benzyl-, benzoyl- and diphenylmethyl-moieties, bound at the 2-position, but not at the 4-position of the pyridine ring, could induce HO. The substituted imidazoles generally produced a potent induction of P 450, and some of them also exhibited HO induction similar to those of the corresponding pyridine compds. Both 2-(4-chlorobenzyl)pyridine and 2-(3,4-dichlorobenzyl)imidazole were more potent inducers of HO than their dechlorinated parent compds. All of these findings suggest that the substituted pyridine and imidazole compds. produce HO and P 450 induction in a regio-related manner with lipophilic moieties, and that the addn. of chlorine atom(s) may alter the magnitude of induction of HO in rat liver. .