Detail of "61566-34-5"

CAS Number:
61566-34-5
Name:
Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-,methyl ester
Molecular Structure:
Formula:
C₁₄H₂₀O₂
Molecular Weight:
220.31
Synonyms:
2-(4-Isobutylphenyl)propionic acid methyl ester;Ibuprofen methyl ester;Methyl2-(4-isobutylphenyl)propionate;Methyl 2-(4'-isobutylphenyl)propanoate;Methyl2-(p-isobutylphenyl)propionate;Methyl α-(4-isobutylphenyl)propionate;Methyl α-(p-isobutylphenyl)propionate;Racemic ibuprofen methyl ester;
EINECS:
262-853-7
Density:
0.976 g/cm³
Boiling Point:
287.1 °C at 760 mmHg
Flash Point:
101.5 °C
Risk Codes:
36/37/38
Safety:
26-36/37/39 Details

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Quantitative determination of ibuprofen by glass capillary gas chromatography using three different methylation methods: Quantitative determination of ibuprofen by glass capillary gas chromatography using three different methylation methods. Heikkinen, Liisa (Sch. Pharm., Univ. Helsinki, Helsinki SF-00170, Finland). Acta Pharm. Fenn., 92(4), 275-82 (English) 1983. CODEN: APHFDO. ISSN: 0356-3456. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 1 Ibuprofen (I) [15687-27-1] was methylated by 3 different methods: HCl-MeOH, BF3-MeOH, and PhNMe3OH-MeOH for anal. by gas chromatog. (GC). A flame ionization detector connected to a peak integrator, glass capillary columns, He carrier gas and a SE-30 column were used. Ibufenac(II) and 3,5-dimethoxybenzoic acid [61566-34-5] were used as internal stds. GC-mass spectra were given. The 1st and 3rd methylation reagents gave good precision and accuracy but the 3rd was more rapid and simple. I was detd. in concns. of 5-50 mg/mL.

(Isobutylphenyl)acetic acid and (isobutylphenyl)propionic acid: (Isobutylphenyl)acetic acid and (isobutylphenyl)propionic acid. Bruzzese, Tiberio; Cambieri, Maurizio; Ferrari, Rodolfo (SPA Societa Prodotti Antibiotici S.p.In this study， 61566-34-5 and 61566-33-4 are also used.A., Italy). Ger. Offen. DE 2614306 21 Oct 1976, 19 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07C063-52. PRIORITY: GB 75-13670 3 Apr 1975. DOCUMENT TYPE: Patent CA Section: 25 (Noncondensed Aromatic Compounds) Reaction of 4-Me2CHCH2C6H4COMe with MeOH in the presence of Tl(NO3)3.cntdot.3H2O and HClO4 gives after 1 hr at room temp. 91% 4-Me2CHCH2C6H4CH2CO2Me which is hydrolyzed to give 4-Me2CHCH2C6H4CH2CO2H and methylated with MeI in liq. NH3 in the presence of NaNH2 to give 4-Me2CHCH2C6H4CHMeCO2H (I). I is also prepd. directly from 4-Me2CHCH2C6H4COEt by the foregoing procedure and hydrolysis of the Me ester. .