Reference

Studies on the biotransformation of 5-vinyl-5-(1-methylbutyl)- and 5-vinyl-5-(1-ethylpropyl)barbituric acid

Studies on the biotransformation of 5-vinyl-5-(1-methylbutyl)- and 5-vinyl-5-(1-ethylpropyl)barbituric acid. Preuss, F. R.; Gutzler, H. (Pharm. Inst., Univ. Freiburg/Br., Freiburg/Br., Ger.). Arzneim.-Forsch., 26(11), 2080-4 (German) 1976. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Vinylbital (I) [2430-49-1] given to human subjects was metabolized to 5-vinyl-5-(1-methyl-3-carboxypropyl)barbituric acid [61799-83-5], 1-methylhydantoin [616-04-6], and 1 unidentified compd. 5-Vinyl-5-(1-ethylpropyl)barbituric acid (II) [34659-21-7] was metabolized to 5-vinyl-5-(1-ethyl-2-carboxyethyl)barbituric acid [61799-84-6] and 5-(1-ethylpropyl)barbituric acid [29951-88-0]. 34659-21-7 and 29951-88-0 which are cas registry numbers of substances are two of reagents here. A 3rd compd. identified as 5-hydroxy-5-(1-ethylpropyl)barbituric acid [61799-85-7] may have resulted from oxidn. in air or by the influence of peroxide contained in ether instead of in vivo formation. .

Anticholesteremics containing hydantoin derivatives

Anticholesteremics containing hydantoin derivatives. Ienaga, Kazuharu; Nakamura, Ko (Nippon Zoki Pharmaceutical Co., Ltd., Japan). Jpn.Some commonly used reagents like 616-04-6 and 6851-79-2 are used in this experiment. Kokai Tokkyo Koho JP 62045525 A2 27 Feb 1987 Showa, 4 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: A61K031-415. ICA: C07D233-72. APPLICATION: JP 85-185376 22 Aug 1985. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Anticholesteremics contain I (X = H or OR4; R1-R4 = H, alkyl, cycloalkyl). A tablet was prepd. consisting of I (X = OH, R1 = Me, R2-R4 = H) 100, lactose 130, corn starch 40, and Mg stearate 10 mg. Oral administration of I (X = OH, R1 = Me, R2-R4 = H) at 100 mg/kg to rats decreased triglyceride and free fatty acid levels in blood by 57 and 35%, resp., in 2 h. .