Reference

Isolation and identification of some metabolites of mephenoxalone (control-OM) from human urine

Isolation and identification of some metabolites of mephenoxalone (control-OM) from human urine. Eckhardt, G.; Goenechea, S.; Gielsdorf, W. (Inst. Org. Biochem., Univ. Bonn, Bonn, Ger.). J. Clin. Chem. Clin. Biochem., 15(3), 115-20 (German) 1977. CODEN: JCCBDT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Mephenoxalone (I) [70-07-5] was degraded by various routes in the human, and some was excreted unchanged. In the metab. of I, the phenoxymethyl ether bond was cleaved; thus o-methoxyphenol [90-05-1] was identified in urine and 3-amino-1,2-propanediol [616-30-8] was found after alk. hydrolysis. Hydroxylation of the benzene ring produced a phenolic hydroxymephenoxalone (II) [63368-98-9], and demethylation converted I into demethylmephenoxalone (III) [63257-75-0]. Opening of the oxazolidone ring led to the prodn. of l-(o-methoxyphenoxy)-3-aminopropane-2-ol (IV) [63257-76-1]. Urine contained 2 further substances l-(o-hydroxyphenoxy)-3-amino-1-propene (V) [63257-77-2] and dehydromephenoxalone (VI) [63179-47-5]. V may be an artifact. II, III and VI could be detected after acid hydrolysis and enzymic cleavage with .beta.-glucuronidase/aryl sulphatase, whereas IV and V were detected only after acid hydrolysis. Thin layer chromatog. revealed 3 further metabolites, which were not identified.

First injectable poly(vinyl alcohol) hydrogel formed by mixing of functional PVA components

All Rights Reserved. First injectable poly(vinyl alcohol) hydrogel formed by mixing of functional PVA components.In this study， 25415-88-7 and 616-30-8 are also used. Ossipov, Dmitri A.; Hilborn, Joens (Department of Material Science, Uppsala University, Uppsala 75121, Swed.). Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 47(1), 136-137 (English) 2006 American Chemical Society, Division of Polymer Chemistry. CODEN: ACPPAY. ISSN: 0032-3934. DOCUMENT TYPE: Journal; (computer optical disk) CA Section: 35 (Chemistry of Synthetic High Polymers) We describe the development of an injectable, in situ chem. hydrogel forming system. The gelation occurs under neutral conditions and room temp. immediately upon mixing of two aq. solns. of the poly(vinyl alc.) components esp. derivatized with aldehyde and hydrazide functional groups resp. Aldehyde and hydrazide pendant groups were incorporated with low SD into PVA backbone through the carbonate linkages in order to keep PVA structural homogeneity unaltered. As a result, the hydrazone crosslinks are formed rapidly between aldehyde and hydrazide pendant groups when the correspondingly modified PVA components are brought in contact as water solns. The rapid gelation under physiol. conditions demonstrates the capacity of the elaborated system for in situ hydrogel formation which in combination with naturally biodegradable polymer usage can be a good candidate for injectable cell delivery system. .