Detail of "6164-87-0"

Reference

Galenic study of oral sustained-release drugs based on inert matrixes: national drug market

Galenic study of oral sustained-release drugs based on inert matrixes: national drug market. Socias, Maria S.; Sune, J. Maria; Cerezo, A. (Fac. Farm., Univ. Granada, Granada, Spain). Congr. Nac. Biofarm. Farmacocinet., [Actas], 1st, 383-403. Cons. Gen. Colegios Of. Farm.: Madrid, Spain. (Spanish) 1977. CODEN: 38SAAJ. DOCUMENT TYPE: Conference CA Section: 63 (Pharmaceuticals) Various parameters (dissoln. time, phys. appearance, hardness, wt., active ingredient content, etc.) were detd. for FeSO4, phenformin-HCl [834-28-6], isosorbide dinitrate [87-33-2], and pyridylcarbinol tartrate [6164-87-0] of Spanish prodn.

Pharmacological studies on the peripheral vasodilator nicotinyl tartrate (Ronicol Timespan)

Pharmacological studies on the peripheral vasodilator nicotinyl tartrate (Ronicol Timespan). Yajima, Takashi; Uritani, Katsuko; Nakahara, Tamio; Aoki, Rie; Maeda, Masaki; Tanaka, Yushiro; Nakamura, Kazuo; Nakamura, Keiji (Dep. Pharmacol., Nippon Roche Res. Cent., Kamakura, Japan). Oyo Yakuri, 14(1), 153-78 (Japanese) 1977. CODEN: OYYAA2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Nicotinyl tartrate (I) [6164-87-0] and nicotinic acid [59-67-6] at the i.v. doses of 1-3 mg/kg exerted a short lasting increase in arterial blood flow and a decrease in the vascular resistance of femoral, vertebral and coronary vascular systems in pentobarbital-anesthetized dogs without causing any change in cardiac output, left ventricular constricting force, aortic blood pressure, heart rate, ECG-II pattern and respiration. Effects of I tended to be longer lasting than those of nicotinic acid. Further, I caused no effect on the hemodynamic changes to norepinephrine, acetylcholine, histamine and angiotensin-II. Vasodilating effects of I and nicotinic acid were also demonstrated in the isolated rabbit's ear perfusion system moderately constricted with KCl, the intact mouse ear, and by slight but significant prevention of frostbite of the rat's hindpaw induced by immersion into dry-ice cold ethanol soln. at -48°. The potency of I was greater in the former two systems and less in the flush response in the intact mouse ear than the potencies of nicotinic acid. General pharmacol. studies of I at nonpharmacol. large doses indicate no significant influence on the following: gross behaviors in mice and rats, combination effects with d-methamphetamine, Metrazole and reserpine in mice, rectal temp. in rats, spontaneous and arousal EEG activities to photic, auditory (bell) and olfactory (acetic acid fume) stimulation in unanesthetized, gallamine-immobilized cats, spinal reflex potentials (monosynaptic, polysynaptic and dorsal root reflexes) in spinal cats, neuromuscular junction (tibial nerve-gastrocnemius muscle prepn.) in anesthetized rats, spontaneous motility of isolated rat's vas deferens, uterus, guinea pig's ileum and the responses to norepinephrine (vas deferens), to isoproterenol (tracheal ring) and to acetylcholine, histamine and BaCl2 (ileum), intestinal propulsive motility of mice, pupil diam. of mice and bile flow rate of rats. However, I prolonged methylhexabital sleep in mice (500 mg/kg, orally), inhibited gastric dilatation-enhanced acid and gastric juice output in rats at 200 mg/kg, orally and elevated water and Na diuresis in saline-loaded rats at 100 mg/kg, orally. These effects were either lower than (methylhexabital sleep and gastric secretion) or equal (diuresis) to those of nicotinic acid.