Reference

Alkyl-substituted-tricyclic quinazolinones as bronchodilators

Alkyl-substituted-tricyclic quinazolinones as bronchodilators. Hardtmann, Goetz E. (Sandoz-Wander, Inc., USA). U.S. US 3982000 21 Sep 1976, 7 pp. Division of U.S. 3,905,976. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-505. NCL: 424251000. APPLICATION: US 71-201982 24 Nov 1971. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Imidazoquinazolinones I (R = Me, R1 = Cl, R2 = H; R = 4-FC6H4CH2, R1 = H, R2 = H, 2-Me, 3-Me; R = cyclopropylmethyl, Ph, R1 = R2 = H) were prepd. for use as antihypertensives and bronchodilators (no data).In this experiment, several chemicals are used like 6168-72-5 and 42239-80-5 Thus, II (R3 = SMe), prepd. by methylation of the corresponding thione, was treated with H2NCHMeCH2OH, II (R3 = NHCHMeCH2OH) chlorinated and cyclized to I (R = Me, R1 = Cl, R2 = H). .

Ethylene diamines as anti tubercular drugs: compositions and methods

Ethylene diamines as anti tubercular drugs: compositions and methods. Protopopova, Marina Nikolaevna; Lee, Richard Edward; Slayden, Richard Allan; Barry, Clifton E.; Bogatcheva, Elena; Einck, Leo (USA ). U.S. Pat. Appl. Publ. US 2004019117 A1 29 Jan 2004,158 pp., Cont.-in-part of U.S. Ser. No. 147,587. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K031-137. ICS: A61K031-695; A61K031-44; A61K031-40. NCL: 514649000; 514063000; 514357000; 514408000. APPLICATION: US 2003-441146 19 May 2003. PRIORITY: US 2002-147587 17 May 2002; US 2002-PV381220 17 May 2002. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 10, 23, 63 Methods and compns. for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compns. comprising substituted ethylene diamines R1HNCH2CH(R4)NR2R3 [I; R4 = H, alkyl, aryl, etc.; R1-R3 = H, alkyl, aryl, NH2, etc.] for the treatment of infectious diseases are provided. A chem. library of substituted ethylene diamines I is prepd. on a solid polystyrene support using split and pool technologies. These diamines are screened for anti-TB activity using in vitro assays (data provided). Some of the compds. I such as N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine were selected for testing in vivo. 6168-72-5 and 627523-18-6 are just another two chemicals used in this study. In one embodiment, these methods and compns. are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis. .