Detail of "617-04-9"

Reference

Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors

Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors. Ofek, I.; Mirelman, D.; Sharon, N. (Inst. Microbiol., Hadassah Med. Sch., Jerusalem, Israel). Nature (London), 265(5595), 623-5 (English) 1977. CODEN: NATUAS. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) D-mannose [3458-28-4] and Me .alpha.-D-mannopyranoside (I) [617-04-9] but not N-acetyl-D-glucosamine [7512-17-6] or D-galactose [59-23-4], reversibly inhibited adherence of E. coli K12 or B cells to human oral epithelial cells; inhibition by I was dose-related and linear in the range 2-6 mg sugar/mL. Binding of E. coli to epithelial cells is probably mediated by a mannose-specific lectin-like substance present on the bacterial cell surface which binds to a mannose-like receptor site on the mucosal cell.

Accelerated calcium ion uptake in murine thymocytes induced by concanavalin A

Accelerated calcium ion uptake in murine thymocytes induced by concanavalin A. Ozato, Keiko; Huang, Leaf; Ebert, James D. (Dep. Embryol., Carnegie Inst. Washington, Baltimore, Md., USA). J. Cell. Physiol., 93(1), 153-60 (English) 1977. CODEN: JCLLAX. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Addn. of concanavalin A (I) [11028-71-0] to cultured murine thymocytes enhanced the rate of Ca2+ uptake ~9-fold. The increase in Ca2+ uptake was obsd. 5 min after I addn. and was concn. dependent over a range of 2-400 mg I/mL. The effect was reversed completely by a-methyl mannopyranoside [617-04-9]. Succinyl I [55128-23-9] exhibited only a slight effect compared with native I. Ca2+ uptake was strongly dependent on energy metab. The uptake of CrO42- by thymocytes was also enhanced by I, but the effect of I on CrO42- permeability appeared to be independent of its effect on Ca2+ uptake.