Detail of "617-27-6"

Reference

Optically active or racemic 2-amino-1-propanol

Optically active or racemic 2-amino-1-propanol. Kotva, Rudolf; Cerny, Antonin; Semonsky, Miroslav (Czech. ). Czech. CS 209151 B 1 Feb 1983,2 pp.Chemicals with cas numbers 617-27-6 and 6170-23-6 also play role. (Czech). (Czechoslovakia). CODEN: CZXXA9. CLASS: IC: C07C091-04. APPLICATION: CS 71-8544 8 Dec 1971. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) DL-MeCH(NH2)CO2Et was reduced with NaBH4 in boiling 50% EtOH and the mixt. was distd. in a stream of N. The distillate was made acid with HCl and evapd. in vacuo, crude DL-MeCH(NH2)CH2OH.HCl (83%) was decompd. with alc. EtONa and distd. to give 68.5% pure product. Analogously prepd. was 67.5% L-(+)-MeCH(NH2)CH2OH, which was purified via cryst. hydrogen oxalate. .

A concise synthesis of sterically hindered 3-amino-2-oxindoles

A concise synthesis of sterically hindered 3-amino-2-oxindoles. O'Connor, Stephen J.; Liu, Zheng (Department of Chemistry, Bayer Research Center, West Haven, CT 06437, USA). Synlett, (14), 2135-2138 (English) 2003 Georg Thieme Verlag. CODEN: SYNLES. ISSN: 0936-5214. DOCUMENT TYPE: Journal CA Section: 31 (Alkaloids) Section cross-reference(s): 34 A new method for the synthesis of 3-alkyl-3-amino-2-oxindoles I (R = Me CH2Ph, 2-pyridylmethyl, 3-pyridylmethyl, 4-MeOC6H4CH2) is reported. These compds. are prepd. in a 3-step procedure using a base-mediated nucleophilic addn. of benzylidene-imine protected a-amino esters to 2-nitrofluorobenzene as the key step. The process provides a variety of 3-alkyl-3-amino-2-oxindole analogs in yields of 1-24%. Yields are highest with alanine, phenylalanine and 2-pyridylalanine as the amino acid starting materials, while 3-pyridylalanine and O-methyltyrosine are less efficiently arylated.There are some commonly used reagents with their cas registry numbers 646995-91-7 and 617-27-6 in this article. Sterically hindered amino acids such as valine and phenylglycine are for all practical purposes, not substrates for the key nucleophilic substitution reaction. The resulting 3-alkyl-3-amino-2-oxindoles are important intermediates for the prepn. of drug-like substances. The conversion of alanine Et ester to 3-amino-3-methyl-2-oxindole is described in detail. .