Detail of "61718-82-9"

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CAS Number:
61718-82-9
Name:
1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1)
Superlist Name:
Fluvoxamine maleate
Molecular Structure:
Formula:
C₁₅H₂₁F₃N₂O₂^.C₄H₄O₄
Molecular Weight:
434.46
Synonyms:
2-{[(E)-{5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino]oxy}ethanamine (2Z)-but-2-enedioate (1:1);acide (2Z)-but-2-ènedio?que - 2-[({(1E)-5-méthoxy-1-[4-(trifluorométhyl)phényl]pentylidène}amino)oxy]éthanamine (1:1);MK 264 {Maleate};
Melting Point:
120-121.5 °C
Boiling Point:
370.6 °C at 760 mmHg
Flash Point:
177.9 °C
Solubility:
Soluble in water
Appearance:
white crystalline powder
Hazard Symbols:
Xn; Xi
Risk Codes:
22-36/37/38
Safety:
36-36/37/39-27-26 Details

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Reference

Fluvoxamine maleate: metabolism in man: Fluvoxamine maleate: metabolism in man. Overmars, H.; Scherpenisse, P. M.; Post, L. C. (Duphar - Res. Lab., Weesp, Neth.). Eur. J. Drug Metab. Pharmacokinet., 8(3), 269-80 (English) 1983. CODEN: EJDPD2. ISSN: 0398-7639. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The metabolic fate of fluvoxamine maleate (I) [61718-82-9] in man was investigated. The metabolites were isolated from the pooled urines of healthy volunteers who had ingested either 5 mg radioactive, or 100 mg nonradioactive fluvoxamine maleate as a single dose. The main isolation methods were solvent extn., column and thin-layer chromatog. Eleven metabolites were isolated; 8 of these were carboxylic acids. Identification of 9 metabolites was accomplished by mass spectrometry supported by information from the UV spectra and the ionogenic properties. The main route of metabolic degrdn. of fluvoxamine begins with oxidative elimination of the methoxyl group, another route begins with removal of the primary amino group.In this experiment, several chemicals are used like 88699-84-7 and 88699-90-5 In view of the nature of the degrdn. pattern, none of the metabolites is likely to possess psychotropic activity. For the two primary metabolites this has, in effect, been demonstrated. .

Fluvoxamine: metabolic fate in animals: Fluvoxamine: metabolic fate in animals. Ruijten, H. M.; De Bree, H.; Borst, A. J. M.; De Lange, N.; Scherpenisse, P. M.; Vincent, W. R.; Post, L. C. (Res. Lab., Duphar B. V., Weesp, Neth.). Drug Metab. Dispos., 12(1), 82-92 (English) 1984. CODEN: DMDSAI. ISSN: 0090-9556. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The metabolic fate in animals of the antidepressant fluvoxamine maleate (I) [61718-82-9] was investigated. 88699-87-0 and 89035-98-3 which are cas registry numbers are also used here. The 14C-labeled drug was administered orally to dogs, rats, hamsters, and mice, and excretion in urine and feces was measured. Chromatog. patterns of the urines were developed by high-performance liq. chromatog. (HPLC). These patterns were used as guides in the isolation of the metabolites, the initial step consisting of concn. of the radioactivity in the urine pools in a conical precolumn, followed by sepn. in the same HPLC system as used for the metabolite patterns. Altogether, 32 radioactive substances were isolated from the urine pools of the 4 animal species. They were all identified by the combined use of proton NMR and mass spectrometry, and by information obtained from chromatog. behavior and color reactions. Several of the 32 compds. were identical, leaving a total of 11 different metabolites in the 4 species. In all the animal species, the main focus of fluvoxamine degrdn. was its aliph. OMe group. In 3 species, this resulted in the corresponding carboxylic acid as the main metabolite, but in the mouse the corresponding alc., in glucuronidated form, was at least as important. In the mouse and hamster, the Me ester was a minor metabolite. Products of acetylation or oxidative removal of the primary NH2 group accounted for only minor proportions of the metabolite patterns. While fluvoxamine itself has the (E)-configuration, several metabolites occurred both in the (E)- and the (Z)-form. The parent compd. was isolated only from the urine of dogs; it accounted for <10% of the urinary radioactivity. .

Detail of "61718-82-9"

1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1)

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CAS No.61718-82-9 Fluvoxamine maleate

CAS No.61718-82-9 Fluvoxamine maleate

CAS No.61718-82-9 Fluvoxamine maleate

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Reference