Detail of "61756-22-7"

CAS Number:
61756-22-7
Name:
L-Glutamic acid,L-valylglycyl-L-seryl-
Molecular Structure:
Formula:
C₁₅H₂₆N₄O₈
Molecular Weight:
390.39
Synonyms:
L-Glutamic acid,N-[N-(N-L-valylglycyl)-L-seryl]-;1-L-Valineeosinophilotactic peptide;(S)-2-((S)-2-(2-((S)-2-Amino-3-methylbutanamido)acetamido)-3-hydroxypropanamido)pentanedioic acid;L-Valylglycyl-L-seryl-L-glutamic acid;Eosinophilotactic peptide;Eosinophilotactic peptide, 1-L-valine-;NSC 350591;Val-Gly-Ser-Glu;
Density:
1.366 g/cm³
Boiling Point:
849.409 °C at 760 mmHg
Flash Point:
467.506 °C

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The ECF-A tetrapeptides and histamine selectively enhance human eosinophil complement receptors: The ECF-A tetrapeptides and histamine selectively enhance human eosinophil complement receptors. Anwar, A. R. E.; Kay, A. B. (Med. Sch., Univ. Edinburgh, Edinburgh, Scot.). Nature (London), 269(5628), 522-4 (English) 1977. CODEN: NATUAS. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Increasing concns. (10-6, 10-5, 10-4 mol/L) of the ECF-A tetrapeptides, Val-Gly-Ser-Glu (I) [61756-22-7] and Ala-Gly-Ser-Glu (II) [61756-28-3], and histamine [51-45-6] dose-dependently enhanced the nos. of human eosinophils, but not neutrophils, forming rosettes with complement-coated sheep red blood cells (EAC3b); there was no increase in the nos. of eosinophils or neutrophils forming rosettes with IgG-coated sheep red blood cells. Enhancement of EAC3b eosinophil rosettes by I, II, or histamine increased with incubation time; with I and II, most of the increase in rosette formation occurred within 40 min whereas with histamine, enhancement of rosette formation took place between 40 and 80 min. Thus ECF-A peptides and histamine attract eosinophils selectively in chemotaxis; they may also have a direct effect on the eosinophil membrane as shown by the apparent increase in the nos. of complement receptors.