CAS No.6199-67-3,CUCURBITACIN B Suppliers

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Basic Information

Molecular Structure:
CAS No.:	6199-67-3
Name:	CUCURBITACIN B

Formula:	C₃₂H₄₆O₈
Molecular Weight:	558.712
Synonyms:	19-Nor-9b,10a-lanosta-5,23-diene-3,11,22-trione, 2b,16a,20,25-tetrahydroxy-9-methyl-, 25-acetate (7CI,8CI);(+)-Cucurbitacin B;Amarine;Cucurbitacine B;NSC 144154;NSC49451;Cucurbitacin B;[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate;Cucurbitacin B hydrate;
Density:	1.23 g/cm³
Melting Point:	184-186oC
Boiling Point:	699.3 °C at 760 mmHg
Flash Point:	218.7 °C
Appearance:	White powder
Hazard Symbols:	T
Risk Codes:	25
Safety:	45-24/25
PSA:	138.20000
LogP:	3.49930

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Chemistry

CUCURBITACIN B's Molecular formula: C₃₂H₄₆O₈
CUCURBITACIN B's Molar mass: 558.7
Synonyms: (2beta,9beta,10alpha,16alpha,23e)-thyl;19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25;19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet;19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me;25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr;cucurbitacineb;AMARINE;1,2-DIHYDRO-ALPHA-ELATERIN

Toxicity Data With Reference

1.	orl-mus LD50:14 mg/kg	CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605.
2.	scu-mus LD50:1 mg/kg	CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605.
3.	ims-mus LD50:2730 µg/kg	CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intramuscular	2730ug/kg (2.73mg/kg)	Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992.
mouse	LD50	oral	14mg/kg (14mg/kg)	Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992.
mouse	LD50	subcutaneous	1mg/kg (1mg/kg)	Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992.

Safety Profile

A poison by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits acrid smoke and irritating vapors.

Safety Info
Symbol:	GHS06
Sign:	Danger
hazard declaration:	H300
hazard declaration add:
waring notice:	P264; P301 + P310

Specification

Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells. In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.