Reference

Thiazolidine derivatives

Thiazolidine derivatives. Kawamatsu, Yutaka; Fujita, Takeshi; Yamamoto, Yujiro (Takeda Chemical Industries, Ltd.; Senju Pharmaceutical Co., Ltd., Japan). Eur. Pat. Appl. EP 91761 A2 19 Oct 1983, 14 pp. DESIGNATED STATES: R: BE, CH, DE, FR, GB, IT, LI, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D277-34.Several substances with their cas registry numbers 496-11-7 and 62-56-6 may be metioned in this study. ICA: C07D277-54. APPLICATION: EP 83-301847 31 Mar 1983. PRIORITY: JP 82-62223 13 Apr 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Thiazolidine-2,4-diones I (n = 1, 2, 3), which were prepd., showed their usefulness in the treatment of diabetic cataract and neuropathy. Thus, a mixt. of Et 2-chloro-2-(5-indanyl)acetate and thiourea in EtOH was refluxed, HCl was added, and the mixt. was refluxed and worked up to give I (n = 1). At 25 mg/kg in rats, made diabetic by streptozotocin, I (n = 1) caused 62% inhibition of sorbitol accumulation in the lens and 66% inhibition in the sciatic nerve. .

Synthesis of methyl 2-deoxy-4,5:6,7-di-O-isopropylidene-D-arabino-hept-3-ulosonate and its use in the preparation of D-arabino-tetrahydroxybutylpyrimidine derivatives

Synthesis of methyl 2-deoxy-4,5:6,7-di-O-isopropylidene-D-arabino-hept-3-ulosonate and its use in the preparation of D-arabino-tetrahydroxybutylpyrimidine derivatives. Valpuesta Fernandez, Maria; Lopez Herrera, Fidel J.; Gomez Perez, Cristina (Dep. Quim. Org., Univ. Malaga, Spain). Carbohydr. Res., 124(2), 333-7 (English) 1983. CODEN: CRBRAT. ISSN: 0008-6215. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Section cross-reference(s): 28 Reaction of 2,3:4,5-di-O-isopropylidene-aldehydo-D-arabinose with Me diazoacetate in dry ether catalyzed by BF3. 62-56-6 and 6832-16-2 which are cas registry numbers of substances are two of reagents here.Et2O gave 57% title heptulosonate I. I on cyclocondensation with S-methylthiourea, thiourea, and guanidine gave pyrimidines II (R = SMe, SH, NH2), which on treatment with MeOH-HCl gave (tetrahydroxybutyl)pyrimidines III. .