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CAS No.: | 622-40-2 |
---|---|
Name: | 2-Morpholinoethanol |
Article Data: | 69 |
Molecular Structure: | |
Formula: | C6H13NO2 |
Molecular Weight: | 131.175 |
Synonyms: | 2-(4-Morpholino)ethylalcohol;2-(4-Morpholinyl)-1-ethanol;2-(4-Morpholinyl)ethanol;4-(2-Hydroxyethyl)morpholine;N-(2-Hydroxyethyl)morpholine;N-(b-Hydroxyethyl)morpholine;NSC1946;b-Morpholinoethanol;N-(2-Hydroxyethyl) Morpholine;4-Morpholineethanol; |
EINECS: | 210-734-5 |
Density: | 1.06 g/cm3 |
Melting Point: | -1 °C |
Boiling Point: | 224.4 °C at 760 mmHg |
Flash Point: | 99.4 °C |
Solubility: | miscible with water |
Appearance: | clear colourless to yellow liquid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36-37/39 |
PSA: | 32.70000 |
LogP: | -0.75120 |
Conditions | Yield |
---|---|
With triphenylphosphine; ruthenium trichloride at 120℃; for 2h; | 100% |
Conditions | Yield |
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at 80℃; for 72h; | 85% |
With potassium carbonate In acetonitrile for 3h; Reflux; | 83% |
With potassium carbonate In acetonitrile for 3h; Reflux; | 83% |
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile for 48h; Heating; | 83% |
at 90 - 170℃; | |
With potassium carbonate at 120℃; | |
With ethanol; copper |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0 - 50℃; for 8h; | 76.6% |
Conditions | Yield |
---|---|
With sodium hydroxide at 40 - 45℃; | 67% |
With acetone | |
With benzene |
Conditions | Yield |
---|---|
With water at 0℃; | |
With methanol |
Conditions | Yield |
---|---|
With sulfuric acid at 160 - 170℃; | |
With cation exchanger at 160 - 220℃; | |
With sulfuric acid at 130 - 150℃; for 15h; |
triethanolamine hydrochloride
A
morpholine
B
2-(morpholin-4-yl)ethanol
C
1,2-dimorpholylethane
D
2,2'-dimorpholinodiethyl ether
Conditions | Yield |
---|---|
at 190 - 230℃; |
Conditions | Yield |
---|---|
at 200 - 205℃; under 40 Torr; anschliessend Erhitzen mit wss.-aethanol. KOH; | |
at 200 - 205℃; under 40 Torr; | |
at 280℃; under 7 Torr; anschliessend Erhitzen mit wss.-aethanol. KOH; |
Conditions | Yield |
---|---|
With ammonium hydroxide at 65 - 80℃; under 2206.5 - 3677.5 Torr; anschliessend Behandeln mit wss. NaOH; |
IUPAC Name: 2-Morpholin-4-ylethanol
Molecular Formula: C6H13NO2
Molecular Weight: 131.17 g/mol
Molecular structure of 4-Morpholineethanol (CAS NO.622-40-2):
EINECS: 210-734-5
Melting Point: -1 °C
Boiling Point: 227 °C at 757 mm Hg(lit.)
Density: 1.083 g/mL at 25 °C(lit.)
Refractive Index: n20/D 1.476(lit.)
Flash Point: 211 °F
Water Solubility: miscible
Molar Refractivity: 34.48 cm3
Molar Volume: 123.6 cm3
XLogP3-AA: -0.8
H-Bond Donor: 1
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Exact Mass: 131.094629
MonoIsotopic Mass: 131.094629
Topological Polar Surface Area: 32.7
Heavy Atom Count: 9
Canonical SMILES: C1COCCN1CCO
InChI: InChI=1S/C6H13NO2/c8-4-1-7-2-5-9-6-3-7/h8H,1-6H2
InChIKey: KKFDCBRMNNSAAW-UHFFFAOYSA-N
Classification Code: Mutation data; Skin / Eye Irritant
4-Morpholineethanol (CAS NO.622-40-2) is commonly used in organic synthesis. It is also a kind of very important chemical pharmaceutical intermediates.
1. | skn-rbt 10 mg/24H open | JIHTAB Journal of Industrial Hygiene and Toxicology. 30 (1948),63. | ||
2. | eye-rbt 20 mg SEV | AJOPAA American Journal of Ophthalmology. 29 (1946),1363. | ||
3. | dns-rat:lvr 5 g/L | MUREAV Mutation Research. 136 (1984),153. | ||
4. | orl-rat LD50:5500 mg/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),16. | ||
5. | ipr-mus LD50:3600 mg/kg | CANCAR Cancer. 2 (1949),1055. | ||
6. | scu-mus LD50:2650 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 109 (1957),108. | ||
7. | par-mus LDLo:4800 mg/kg | CBCCT* “Summary Tables of Biological Tests” National Research Council Chemical-Biological Coordination Center. 7 (1955),691. | ||
8. | skn-gpg LD50:2500 mg/kg | JIHTAB Journal of Industrial Hygiene and Toxicology. 30 (1948),63. |
Reported in EPA TSCA Inventory.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 1
RTECS: QE3510000
F: 10-23
HS Code: 29349990
Moderately toxic by skin contact, subcutaneous, and intraperitoneal routes. Mildly toxic by ingestion and parenteral routes. Mutation data reported. A skin and severe eye irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
4-Morpholineethanol (CAS NO.622-40-2) is also named as 2-(4-Morpholinyl)ethanol ; 2-Morpholinoethanol ; 4-(2-Hydroxyethyl)morpholine ; 4-27-00-00056 (Beilstein Handbook Reference) ; AI3-03872 ; BRN 0104375 ; Ethanol, 2-(morpholinyl)- ; Ethanol, 2-morpholino- ; Hydroxyethylmorpholine ; Morpholine ethanol ; Morpholineethanol ; N-(2-Hydroxyethyl)morfolin ; N-(2-Hydroxyethyl)morfolin [Czech] ; N-(2-Hydroxyethyl)morpholine ; N-beta-Hydroxyethylmorpholine ; NSC 1946 ; beta-Morpholinoethanol ; beta-Oxyaethyl-morpholin ; beta-Oxyaethyl-morpholin [German] ; beta-Oxyaethyl-morpholin [German] . 4-Morpholineethanol (CAS NO.622-40-2) is clear colourless to yellow liquid.