Reference

Molar Cotton-Mouton constants and anisotropy of magnetic susceptibility of benzyl chlorides and bromides

Molar Cotton-Mouton constants and anisotropy of magnetic susceptibility of benzyl chlorides and bromides. Vul'fson, S. G.; Dianova, O. M.; Vereshchagin, A. N. (Inst. Org. Fiz. Khim., Kazan, USSR). Izv. Akad.Several substances with their cas registry numbers 622-95-7 and 20488-10-2 may be metioned in this study. Nauk SSSR, Ser. Khim., (7), 1552-7 (Russian) 1986. CODEN: IASKA6. ISSN: 0002-3353. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) Calcd. and exptl. Cotton-Mouton consts. were compared for RC6H4CHR1X (R = H, 4-Cl, 4-Br, 2-Cl, 2-Br, CH2Br; R2 = H, Me; X = Cl, Br), and the results were discussed in terms of p-s hyperconjugation. .

Preparation of quinolones as antivirals

All Rights Reserved. Preparation of quinolones as antivirals. Kumar, Dange Vijay; Rai, Roopa (Virobay, Inc., USA). PCT Int. Appl. WO 2007005779 A2 11 Jan 2007, 50pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English).Several reagents with their cas registry numbers 622-95-7 and 918790-24-6 are used here. (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-US25889 29 Jun 2006. PRIORITY: US 2005-696063P 1 Jul 2005; US 2006-478371 28 Jun 2006. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 63 Title compds. [I; R1 = AR7; A = (substituted) alkylene; R7 = (substituted) cycloalkyl, aryl, heteroaryl, heterocycloalkyl; R2 = COR8, CO2R9, CONR10R11, NR12R13, etc.; R3 = H, alkyl, halo, alkoxy, OH, haloalkoxy, haloalkyl; R4 = R3, alkylthio, alkylsulfonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, aryloxy, carboxyalkyl, etc.; R5 = R3, aryl, aralkyl, heteroaryl, cycloalkyl, heterocycloalkyl, etc.; R6 = H, alkyl, halo, alkoxy, alkylamino, dialkylamino, Ph, heteroaryl, CO2H, alkoxycarbonyl, (substituted) heterocycloalkylalkoxycarbonyl; R7 = (substituted) cycloalkyl, aryl, heteroaryl, heterocycloalkyl; R8 = cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl; R9 = alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl; R10 = H, alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl; R11 = alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl; R12 = R10, hydroxyalkyl, alkoxyalkyl, heterocycloalkylalkyl; R13 = R10, cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl; with specific exceptions], were prepd. Thus, 1-(4-chlorobenzyl)-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline- 3-carboxylic acid 4-chlorobenzyl ester was prepd. in 6 steps from di-Et ethoxymethylenemalonate, 3,4-difluoroaniline, 4-chlorobenzyl bromide, and N-tert-butoxycarbonylpiperazine. In a hepatitis C virus (HCV) replicon assay, several I showed replication inhibition with IC50's of <5 mM. .