Detail of "6223-83-2"

Reference

Study of the production of 9-fluorenone-4-carboxylic acid anilide using statistical methods of experiment planning

Study of the production of 9-fluorenone-4-carboxylic acid anilide using statistical methods of experiment planning. Stepnova, G. M.; Trigubenko, V. A. (USSR). Izv. Tomsk. Politekh. Inst., 274, 88-90 (Russian) 1976. CODEN: ITPKAM. ISSN: 0368-0487. DOCUMENT TYPE: Journal CA Section: 26 (Condensed Aromatic Compounds) Using statistical methods, an equation was developed to express the effect of reaction time and temp. 6223-83-2 which is the cas registry number of some chemical is mentioned. on the yield of the title compd. (I), prepd. from 4-carboxyfluorenone, PCl5, and PhNH2. The max. yield of I (95%) was obtained at 115° and 95 min. .

A new base-labile anchoring group for polymer-supported peptide synthesis

A new base-labile anchoring group for polymer-supported peptide synthesis. Mutter, Manfred; Bellof, Dieter (Inst. Org. Chem., Univ. Basel, Basel CH-4056, Switz.). Helv. Chim. Acta, 67(7), 2009-16 (English) 1984. CODEN: HCACAV. ISSN: 0018-019X. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 25 A new base-labile anchoring group for polymer-supported peptide synthesis was derived from fluorene I (R = R1 = H) (II). II was prepd. from biphenyl III in several steps in an overall yield of 53% using std. methods. The above group exhibits properties similar to those of the 9-fluorenylmethoxycarbonyl group; it is stable to acid and can be cleaved by 15% piperidine in DMF. Thus, II was esterified with 2,4,5-Cl3C6H2OH (TcpOH) by DCC to give I (R = Tcp, R1 = H), which was condensed with Boc-Val-OH (Boc = Me3CO2C) by DCC to give I (R = Tcp, R1 = Boc-Val), which was coupled with H-Gly-NHCH2Q (Q = styrene-2%-divinylbenzene copolymer) to give polymer-bound deriv. IV. IV was used in the stepwise synthesis of H-Leu-Ala-Gly-Val-OH. II was condensed with amino-poly(ethylene glycol) monomethyl ether (M-PEG-NH2) by DCC to give I (R = NH-PEG-M, R1 = H), which can be used in liq.Several substances are used for example 6223-83-2 which is its cas registry number.-phase peptide synthesis. .