Detail of "6230-93-9"

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Tissue distribution, elimination, and metabolism of O-ethyl, O-4-nitrophenyl phenylphosphonothioate in hens following daily dermal doses

Tissue distribution, elimination, and metabolism of O-ethyl, O-4-nitrophenyl phenylphosphonothioate in hens following daily dermal doses. Abou-Donia, Mohamed B.; Abdel-Kader, Hassan M.; Abou-Donia, Sherif A. (Med. Cent., Duke Univ., Durham, NC 27710, USA). J. Am. Coll. Toxicol., 2(6), 391-404 (English) 1983. CODEN: JACTDZ. ISSN: 0730-0913. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The absorption, distribution, elimination, and metab. of the insecticide EPN (I) [2104-64-5] were studied in the hen. A daily dermal dose of 0.5 mg/kg (0.56 mCi/dose) of [14C]EPN was applied for 10 consecutive days. Three treated hens were killed at each of the following time intervals: 1, 5, 10, and 15 days after the administration of the last dose. A total of 65% of the cumulative dose was excreted in the combined urinary and fecal excrement 15 days after the last dose. Small amts. of radioactivity were deposited in the egg yolk (0.8%) and the egg albumen (0.3%). No 14CO2 was detected in the expired air. Radioactivity in the tissues reached a peak of 12% of the total administered dose 1 day after the last dose; 14C decreased to 1.5% of the total dose 15 days after the administration of the last dose. The concn. of radioactivity was highest in the liver, followed by the kidney, gall bladder, bile, small intestine, ceca, large intestine, and skin. Relatively low concns. of 14C were detected in the central and peripheral nervous tissues. O-Et phenylphosphonic acid (EPPA) [4546-19-4] was identified as the major urinary-fecal metabolite followed by phenylphosphonic acid (PPA) [1571-33-1] and O-Et phenylphosphonothioic acid (EPPTA) [6230-93-9]. EPN accounted for most of the radioactivity in tissues except in the liver. In this tissue, most of the radioactivity was identified as EPPA, EPPTA, and PPA.Except for chemicals metioned above, 2104-64-5 is also used. .

Degradation of EPN in soils under laboratory conditions

Degradation of EPN in soils under laboratory conditions. Wakabayashi, Takeshi; Igarashi, Hajime; Yamamoto, Izuru (Biol. Chem. Res. Lab., Nissan Chem. Ind., Saitama 349-02, Japan). Nippon Noyaku Gakkaishi, 8(2), 155-65 (English) 1983. CODEN: NNGADV. ISSN: 0385-1559. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Section cross-reference(s): 19 The degrdn. of phenyl-U-14C-labeled EPN [2104-64-5] and [p-nitrophenyl-U-14C]EPN was studied in 3 soils under lab. conditions. Persistence of EPN was influenced by soil type and moisture condition. Half-life at 1 ppm dose level was in upland conditions ~30 days for Utsunomiya volcanic ash soil and ~90 days for Taketoyo diluvial soil. In submerged conditions, it was 7-15 days for Utsunomiya soil and 3-7 days for Konosu alluvial soil. In upland soils, degrdn. products were EPN-oxon [2012-00-2], desethyl EPN-oxon [57072-35-2], p-nitrophenol [100-02-7], O-Et S-Me phenylphosphonothiolate [57557-79-6], O-Et O-Me phenylphosphonate [61733-60-6], O-Et H phenylphosphonate [4546-19-4] and H phenylphosphonate [1571-33-1]. The latter 2 were found only when the soils were extd. after acid treatment, indicating their strong adsorption to soils. In submerged soils, all the degrdn. products from upland soils were found, except desethyl EPN-oxon; O-Et H phenylphosphonothioate [6230-93-9] and amino-EPN [18288-54-5] were found in addn. In a sterilized soil (submerged Utsunomiya soil), the degrdn. of EPN was almost suppressed, indicating the importance of microbial degrdn. When incubated with Bacillus subtilis in a liq. medium, EPN was degraded rapidly and the degrdn. products formed were the same as those found in the submerged soils.