Reference

N-Heterocyclic compounds as radioprotectors

N-Heterocyclic compounds as radioprotectors. 1. 2-Pyridinemethanethiol, 2-pyrazinemethanethiol and related compounds. Barnes, John H.; Fatome, Marc; Esslemont, George F.; Jones, Christopher E. L. (Dep. Chem. Metall., R. Mil. Coll.Several reagents with their cas registry numbers 625-57-0 and 31640-94-5 are used here. Sci., Shrivenham/Wiltshire SN6 8LA, UK). Eur. J. Med. Chem. - Chim. Ther., 18(6), 515-19 (English) 1983. CODEN: EJMCA5. ISSN: 0009-4374. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 8, 28, 29 Pyridines I [n = 0, 1; R = H, P(O)(ONa)2, CONH2, CSNEt2] and II (m = 0, 1) were prepd., and they showed radioprotective activity. 2-(Chloromethyl)pyridine hydrochloride was treated with tri-Na thiophosphate, and the pH was adjusted to 9 to give I [n = 0, R = P(O)(ONa)2]. Also prepd. was bis(pyrazinylmethyl) disulfide. .

Cationic polymerization of vinyl ethers with a nitrogen or sulfur atom-containing functional group

All Rights Reserved. Cationic polymerization of vinyl ethers with a nitrogen or sulfur atom-containing functional group. Namikoshi, Takeshi; Hashimoto, Tamotsu (Mater. Eng. Course, Grad. Sch. Eng., University of Fukui, Japan). Fukui Daigaku Kogakubu Kenkyu Hokoku, 54(1), 33-40 (Japanese) 2006 Fukui Daigaku Kogakubu. CODEN: FDKHAD. ISSN: 0429-8373. DOCUMENT TYPE: Journal CA Section: 35 (Chemistry of Synthetic High Polymers) To study the possibility of living cationic polymn. of vinyl ethers with a urethane, urea, and thiourethane group [2-vinyloxyethyl phenylcarbamate (I), N-vinyloxyethyl-N'-phenylurea (II), and 2-vinyloxyethyl phenylthiocarbamate (III), resp.] were polymd. with a variety of initiating systems in CH2Cl2 at 0-(-30°). The HCl/ZnCl2-initiated polymn. of vinyl ether 1 proceeded in a living manner to give the polymers with narrow mol. wt. distributions (MWDs) (Mw/Mn = ~1.2). The poly(I) exhibited relatively high glass transition temp. (55°) as a vinyl ether polymers. In contrast, polymn. of vinyl ether II involved side reactions to produce low-mol.-wt. products under the same reaction condition. To examine the effect of the thiourethane group on vinyl ether polymn., the polymn. of Bu vinyl ether was investigated in the presence of a thiourethane model compd. Et thiocarbamate (IV) with the CH3CH(OiBu)OCOCH3/SnCl4 initiating system in CH2Cl2 at -30°. The Mn of the product polymers were in direct proportion to conversion, although their MWDs were somewhat broad (Mw/Mn = ~1.In this experiment, several chemicals are used like 625-57-0 5). On the other hand, the polymn. of the vinyl ether III produced only low-mol.-wt. products. .