Reference

Augmenting effect of captopril on the response to bradykinin of polymodal receptors

Augmenting effect of captopril on the response to bradykinin of polymodal receptors. Mizumura, Kazue; Sato, Jun; Kamazama, Takao (Kankyoigaku Kenkyusho, Nagoya Univ., Nagoya, Japan). Kankyo Igaku Kenkyusho Nenpo (Nagoya Daigaku), 36, 116-17 (Japanese) 1985. CODEN: NDKIA2. ISSN: 0369-3570. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The amplitude and duration of bradykinin [58-82-2] (9 ′ 10-6M)-induced elec. discharge in canine testicular polymodal receptor were markedly increased, whereas the time to induce the elec. discharge was shortened by pretreatment with an inhibitor of angiotensin converting enzyme [9015-82-1], captopril [62571-86-2] (4.6 ′ 10-5M). Thus, the action of bradykinin appears to be hindered by the afore mentioned enzyme.

N-Ethylmaleimide as a new electrophoric derivatizing reagent for the gas chromatography of thiols

N-Ethylmaleimide as a new electrophoric derivatizing reagent for the gas chromatography of thiols. Jemal, Mohammed; Cohen, Allen I. (Squibb Inst. Med. Res., New Brunswick, NJ 08903, USA). Anal. Chem., 57(12), 2407-9 (English) 1985. CODEN: ANCHAM. ISSN: 0003-2700. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) N-Ethylmaleimide [128-53-0] is an excellent electrophoric labeling reagent for gas chromatog. anal. of captopril [62571-86-2] and other thiol compds. using electron capture detection (GC-ECD). The N-ethylsuccinimide captopril deriv. is stable and extractable from complex matrices such as blood, from which it can be isolated without degrdn. The ester of I has a response comparable to that of hexafluoroisopropyl or pentafluorobenzyl ester of captopril. The simple methylation reaction, which is transparent to electron capture detection, effectively lowers the limit of detection, as compared to the electrophoric derivatization reactions which result in a greater background. Less than 10 pg injected can be detected.