Reference

Selective Formation of Six-Membered Cyclic Sulfones and Sulfonates by C-H Insertion

All Rights Reserved. Selective Formation of Six-Membered Cyclic Sulfones and Sulfonates by C-H Insertion. John, Jinu P.; Novikov, Alexei V. (Chemistry Department, University of North Dakota, Grand Forks, ND 58202, USA). Organic Letters, 9(1), 61-63 (English) 2007 American Chemical Society. CODEN: ORLEF7. ISSN: 1523-7060. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Carbethoxy diazosulfones and sulfonates, easily available from corresponding sulfones and sulfonates, undergo C-H insertion with preferential formation of six membered cyclic sulfones and sulfonates. Thus, reaction of the [diazo(ethoxycarbonyl)methyl]sulfonate I in CH2Cl2 contg. 921755-30-8 which is the cas registry number of one of substances is just one of reagents here. Rh2(OAc)4 at room temp. for five hours gave 55% oxathiolane dioxide II. .

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome. Quimby, Steven J.; Shipley, Lisa A.; Shannon, Harlan E.; Ward, John S.; Hansen, Kristian; Olesen, Preben H.; Sauerberg, Per; Sheardown, Malcolm J.; Swedberg, Michael D. B.; Suzdak, Peter; Greenwood, Beverley; Mitch, Charles H.; Brown, Thomas J.; Bymaster, Frank P.; Calligaro, David O.; Dieckman, Donna; Merrit, Leander; Peters, Steven C. (CNS Research Lilly Research Laboratories, Division of Eli Lilly and Company Lilly Corporate, Lilly Corporate Indianapolis, IN 46285, USA). Journal of Medicinal Chemistry, 40(4), 538-546 (English) 1997 American Chemical Society. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 New 1,2,5-thiadiazole-based structures with muscarinic activity have been prepd. and evaluated both for activity as analgesics in the mouse writhing assay and for activity in normalizing spontaneous cluster contractions in ferret jejunum as a model of IBS in humans. (5R,6R)-exo-6-[4-[(4,4,4-Trifluorobutyl)thio]-1,2,5-thiadiazol-3-yl]-1-azab icyclo[3.There are some commonly used reagents with their cas registry numbers 131987-16-1 and 626-88-0 in this article.2.1]octane (35, LY316108/NNC11-2192) was found to offer an exceptional profile combining analgesic potency in mouse writhing (ED50 = 0.1 mg/kg) along with potency for normalization of GI motility (ED50 = 0.17 mg/kg). This combination of GI and analgesic potency suggests 35 as an excellent candidate for evaluation as a potential treatment of IBS. .