Reference

Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol

Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol. Tanaka, Ken; Yasuda, Mari; Ueda, Makoto (Mitsubishi Chemical Corporation, Japan). Eur. Pat. Appl. EP 792936 A2 3 Sep 1997, 18 pp. DESIGNATED STATES: R: CH, DE, FR, GB, IT, LI. 62600-71-9 are also occured in this study. 62600-71-9 are also occured in this study. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C12P041-00. ICS: C12P007-22; C07D303-02. APPLICATION: EP 1997-103346 28 Feb 1997. PRIORITY: JP 1996-41441 28 Feb 1996. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) The present invention provides an industrially advantageous process for the prepn. of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chems., or as intermediates thereof and a simple process for the prepn. of an optically active substituted styrene oxide or 2-amino-1-(substituted phenyl)ethanol useful as medicines, agricultural chems. or intermediates thereof. A 2-halo-1-(substituted phenyl)ethanol represented by the following general formula (I) is allowed to contact, in the presence of a carboxylic anhydride, with an enzyme stereoselectively catalyzing ester interchange to produce an optically active 2-halo-1-(substituted phenyl)ethanol of formula I (wherein X represents a Cl or Br atom and R1, R2, and R3 may be the same or different and each represents H, a halogen atom, a C1-5 alkyl group, a C1-5 haloalkyl group, a C1-5 alkoxy group, a CN group, or a NO2 group, with the proviso that when 2 of R1, R2 and R3 are alkyl groups or alkoxy groups, they may be combined together to form a ring and that all of R1, R2, and R3 are not H atoms at the same time). ..

Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol

Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol. Tanaka, Ken; Yasuda, Mari; Ueda, Makoto (Mitsubishi Chemical Corporation, Japan). Eur. Pat. Appl. EP 792936 A2 3 Sep 1997, 18 pp. DESIGNATED STATES: R: CH, DE, FR, GB, IT, LI. 62600-71-9 are also occured in this study. 62600-71-9 are also occured in this study. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C12P041-00. ICS: C12P007-22; C07D303-02. APPLICATION: EP 1997-103346 28 Feb 1997. PRIORITY: JP 1996-41441 28 Feb 1996. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) The present invention provides an industrially advantageous process for the prepn. of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chems., or as intermediates thereof and a simple process for the prepn. of an optically active substituted styrene oxide or 2-amino-1-(substituted phenyl)ethanol useful as medicines, agricultural chems. or intermediates thereof. A 2-halo-1-(substituted phenyl)ethanol represented by the following general formula (I) is allowed to contact, in the presence of a carboxylic anhydride, with an enzyme stereoselectively catalyzing ester interchange to produce an optically active 2-halo-1-(substituted phenyl)ethanol of formula I (wherein X represents a Cl or Br atom and R1, R2, and R3 may be the same or different and each represents H, a halogen atom, a C1-5 alkyl group, a C1-5 haloalkyl group, a C1-5 alkoxy group, a CN group, or a NO2 group, with the proviso that when 2 of R1, R2 and R3 are alkyl groups or alkoxy groups, they may be combined together to form a ring and that all of R1, R2, and R3 are not H atoms at the same time). ..