Detail of "62658-63-3"

Reference

Simultaneous modeling of bopindolol kinetics and dynamics

Simultaneous modeling of bopindolol kinetics and dynamics. Platzer, Rudolf; Galeazzi, Renato L.; Niederberger, Werner; Rosenthaler, Joachim (Dep. Med., Univ. Bern, Bern 3010, Switz.). Clin. Pharmacol. Ther. (St. Louis), 36(1), 5-13 (English) 1984. CODEN: CLPTAT. ISSN: 0009-9236. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Two mg oral doses of bopindolol [62658-63-3] were given once and then daily for 13 days to 6 healthy subjects. In plasma, no unchanged drug, only the hydrolysis product of bopindolol (referred to as bopindolol concn.) was detectable or could be measured up to 24 h. Chem. assay by HPLC and detn. of total active b-adrenoceptor blocking material by radioreceptor assay gave identical results. The t1/2 was 4 to 5 h. Effects, measured as reductase in exercise-induced tachycardia (REIT) and as the isoproterenol dose ratio (DR - 1), were followed for 96 h. The concn. of bopindolol in plasma (predicted with a 1-compartment body model) could be related to the measured effects by classic effect models for 20 t1/2s. Parameter ests. for kinetic and effect models did not differ after single and repeated doses. With the parameters from the single-dose expt., the time course of the plasma concn. and the effects after the multiple-dose expt. could be adequately predicted for 24 and 96 h. A deep compartment, an active metabolite, or irreversible destruction of the receptor (accounting for the persistence of the effect) could be excluded. The "dissocn. const." of 100 pmol/L (from DR - 1/concn.) and the minimal effective plasma concn. (from REIT/log concn.) of 1 pmol/L suggest that enough receptors are occupied at chem. unmeasurable levels in plasma to induce an effect. The "dissocn. const." detd. in vivo is of the same order as that from in vitro radioligand studies.

Determination of bopindolol using the flow injection technique coupled with solid phase extraction

Determination of bopindolol using the flow injection technique coupled with solid phase extraction. Meireles, Joana; Sklenarova, Hana; Satinsky, Dalibor; Solich, Petr; Araujo, Alberto N.; Montenegro, Maria Conceicao B. S. M. (Faculty of Pharmacy, CEQUP/Department of Physical Chemistry, University of Porto, Oporto 4050, Port.). Journal of Pharmaceutical and Biomedical Analysis, 33(5), 1149-1153 (English) 2003 Elsevier Science B.V. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) In the proposed procedure, the detn. of bopindolol using a flow injection anal. (FIA) technique, with spectrophotometric detection at 635 nm, was described. The method is based on the prodn. of a green, water-sol. complex with ferric ions in acid medium. The automated lab-made FIA system was used for the direct detn. of bopindolol in tablets. Bopindolol was adsorbed onto the solid phase in a mini-column, which was integrated directly into the flow system. 62658-63-3 which is the cas registry number is also used here. The pos. feature of the use of solid phase extn. (SPE) was the pre-concn. of bopindolol (seven times). The sample throughput was 50 samples per h. Using the SPE method, bopindolol was detd. with a linear range from 125 to 1000 mg mL-1 (Relative std. deviation (R.S.D.)=1.87%), with a detection limit (3s) of 70 mg mL-1. The method was applied to the detn. of bopindolol in Sandonorm tablets. The results obtained were compared with a conventional HPLC method, both anal. techniques were in good agreement. .