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Basic Information
| CAS No.: | 6271-78-9 |
|---|---|
| Name: | 6-Chloronicotinamide |
| Article Data: | 13 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H5ClN2O |
| Molecular Weight: | 156.572 |
| Synonyms: | Nicotinamide,6-chloro- (6CI,7CI,8CI);2-Chloro-5-carbamoylpyridine;6-Chloro-3-pyridinecarboxamide;6-Chloronicotinamide;NSC 37821; |
| EINECS: | 228-456-8 |
| Density: | 1.381 g/cm3 |
| Melting Point: | 210-212 °C(lit.) |
| Boiling Point: | 331 °C at 760 mmHg |
| Flash Point: | 154 °C |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 36/37/38-20/21/22 |
| Safety: | 26-36/37/39-22 |
| PSA: | 55.98000 |
| LogP: | 1.53420 |
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Synthetic route
- 33252-28-7
6-chloronicotinonitrile
- 6271-78-9
6-chloro-3-pyridinecarboxamide
Conditions
| Conditions | Yield |
|---|---|
| With manganese(IV) oxide; water In isopropyl alcohol at 50℃; under 5171.62 Torr; for 0.166667h; | 99% |
- 39891-09-3
(6-chloro-pyridin-3-yl)-acetonitrile
- 6271-78-9
6-chloro-3-pyridinecarboxamide
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; 5 wt% ruthenium/carbon; oxygen In tetrahydrofuran at 30℃; for 20h; | 86% |
- 33252-28-7
6-chloronicotinonitrile
- 917-64-6
methyl magnesium iodide
- 60-29-7
diethyl ether
A
- 6271-78-9
6-chloro-3-pyridinecarboxamide
B
- 55676-22-7
3-acetyl-6-chloropyridine
...Expand
Conditions
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride; trichlorophosphate at 120℃; Behandeln des entstandenen 6-Chlor-nicotinsaeure-chlorid mit Benzol und Ammoniak; | |
| With trichlorophosphate Behandeln des Reaktionsprodukts in Aceton mit wss. NH3; |
Conditions
| Conditions | Yield |
|---|---|
| With oxalyl dichloride; benzene Behandeln des Reaktionsgemisches mit wss. NH3; |
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; phosphorus pentachloride; trichlorophosphate |
- 58757-38-3
6-Chloronicotinoyl chloride
- 6271-78-9
6-chloro-3-pyridinecarboxamide
Conditions
| Conditions | Yield |
|---|---|
| With ammonia In toluene at 20℃; for 8h; | 7.15 g |
| With ammonia In diethyl ether | 9 g |
| With ammonia In water at 0℃; for 0.5h; |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: SOCl2 / 4 h / Heating 2: 9 g / NH3 gas / diethyl ether View Scheme | |
| Multi-step reaction with 2 steps 1: SOCl2 / 15 h / Heating 2: 7.15 g / NH3*H2O / toluene / 8 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 25 °C 2: ammonia / water / 0.5 h / 0 °C View Scheme |
- 18368-64-4
2-chloro-5-methylpyridine
- 6271-78-9
6-chloro-3-pyridinecarboxamide
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 60.1 percent / KMnO4 / H2O / 5 h / Heating 2: SOCl2 / 15 h / Heating 3: 7.15 g / NH3*H2O / toluene / 8 h / 20 °C View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: aqueous KMnO4 3: oxalyl chloride; benzene / Behandeln des Reaktionsgemisches mit wss. NH3 View Scheme |
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6-Chloronicotinamide
Chemistry
Molecular Formula: C6H5ClN2O
Molar mass: 156.5697 g/mol
Density: 1.381 g/cm3
Flash Point: 154 °C
Index of Refraction: 1.588
Melting point: 210-212 °C(lit.)
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25°C
Structure of 6-Chloronicotinamide(6271-78-9):
Synonyms of 6-Chloronicotinamide(6271-78-9): 6-chloropyridine-3-carboxamide ;Nicotinamide, 6-chloro- ;3-Pyridinecarboxamide, 6-chloro- ;2-Chloropyridine-5-carboxamide
Product Categoriy of 6-Chloronicotinamide(6271-78-9): Pyridines ;Halopyridines ;Chloropyridines ;Halogenated Heterocycles ;blocks ;Heterocyclic Building Blocks
Molar mass: 156.5697 g/mol
Density: 1.381 g/cm3
Flash Point: 154 °C
Index of Refraction: 1.588
Melting point: 210-212 °C(lit.)
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25°C
Structure of 6-Chloronicotinamide(6271-78-9):
Synonyms of 6-Chloronicotinamide(6271-78-9): 6-chloropyridine-3-carboxamide ;Nicotinamide, 6-chloro- ;3-Pyridinecarboxamide, 6-chloro- ;2-Chloropyridine-5-carboxamide
Product Categoriy of 6-Chloronicotinamide(6271-78-9): Pyridines ;Halopyridines ;Chloropyridines ;Halogenated Heterocycles ;blocks ;Heterocyclic Building Blocks
Safety Profile
Hazard Note: Irritant
Hazard Codes:Xi
,Xn
Risk Statements:
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
Hazard Codes:Xi
,XnRisk Statements:
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection