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CAS No.: | 6292-59-7 |
---|---|
Name: | 4-tert-Butylbenzenesulfonamide |
Article Data: | 17 |
Molecular Structure: | |
Formula: | C10H15NO2S |
Molecular Weight: | 213.301 |
Synonyms: | Benzenesulfonamide,p-tert-butyl- (6CI,8CI);4-(1,1-Dimethylethyl)benzenesulfonamide;NSC 9911;p-(tert-Butyl)phenylsulfonamide;p-tert-Butylbenzenesulfonamide; |
EINECS: | 613-109-9 |
Density: | 1.152 g/cm3 |
Melting Point: | 136-138 °C |
Boiling Point: | 337.2 °C at 760 mmHg |
Flash Point: | 157.7 °C |
Appearance: | white solid |
Hazard Symbols: | Xi |
Risk Codes: | 20/21/22 |
Safety: | 22-36/37/39 |
PSA: | 68.54000 |
LogP: | 3.41260 |
4-tert-butylbenzenesulfonyl chloride
4-tert-butylbenzenesulphonamide
Conditions | Yield |
---|---|
With ammonium hydroxide for 72h; Ambient temperature; | 99% |
With ammonium hydroxide In ethyl acetate at 20℃; for 1h; | 95% |
With ammonium hydroxide In acetone at 20℃; | 94% |
4-tert-butylbenzenesulphonamide
Conditions | Yield |
---|---|
With scandium tris(trifluoromethanesulfonate) In nitromethane at 50℃; for 5h; | 96% |
Conditions | Yield |
---|---|
With chromium(III) acetate hydroxide; periodic acid In acetonitrile at 20℃; for 14h; | 94% |
(4-tert-butylphenyl)diazonium tetrafluoroborate
4-tert-butylbenzenesulphonamide
Conditions | Yield |
---|---|
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 12h; Inert atmosphere; | 84% |
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 12h; Inert atmosphere; Schlenk technique; | 84% |
4-tert-butylbenzenesulphonamide
Conditions | Yield |
---|---|
With chromium(III) acetate hydroxide; periodic acid In acetonitrile at 20℃; for 16h; | 81% |
Conditions | Yield |
---|---|
With [bis(acetoxy)iodo]benzene; ammonium carbamate In methanol at 25℃; for 24h; Inert atmosphere; chemoselective reaction; | 80% |
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; nickel(II) bis(2,2,6,6-tetramethylheptane-3,5-dionate); Ir(dF(CF3)ppy)2(bpy)PF6; zinc dibromide In N,N-dimethyl acetamide at 27℃; for 72h; Inert atmosphere; Irradiation; | 44% |
4-tert-butylbenzenesulphonamide
tert-butylbenzene
4-tert-butylbenzenesulphonamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: chlorosulfonic acid / 6 h / Reflux 2: ethanol / 1 h / 0 °C View Scheme |
4-tert-butylbenzenesulphonamide
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide
Conditions | Yield |
---|---|
Stage #1: 4-tert-butylbenzenesulphonamide; 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine With potassium carbonate In acetonitrile at 25 - 83℃; Large scale reaction; Stage #2: Large scale reaction; | 100% |
With potassium carbonate In dimethyl sulfoxide at 100 - 105℃; | 100% |
Stage #1: 4-tert-butylbenzenesulphonamide With potassium carbonate In toluene at 50℃; for 0.5h; Large scale; Stage #2: 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine With tetrabutylammomium bromide In toluene at 110℃; for 10h; Large scale; | 97% |
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Molecular Structure:
Molecular Formula: C10H15NO2S
Molecular Weight: 213.2966
IUPAC Name: 4-tert-Butylbenzenesulfonamide
Synonyms of 4-tert-Butylbenzenesulfonamide (CAS NO.6292-59-7): Buttpark 44\03-78 ; 4-(tert-Butyl)benzene-1-sulfonamide ; p-tert-Butyl-benzenesulfonamide ; TertiaryButylBenzeneSulphonamide ; 4-(1,1-Dimethylethyl)benzenesulfonamide
CAS NO: 6292-59-7
Melting point: 136-138 ° C
Index of Refraction: 1.536
Molar Refractivity: 57.71 cm3
Molar Volume: 185 cm3
Surface Tension: 40.8 dyne/cm
Density: 1.152 g/cm3
Flash Point: 157.7 °C
Enthalpy of Vaporization: 58.04 kJ/mol
Boiling Point: 337.2 °C at 760 mmHg
Vapour Pressure: 0.000107 mmHg at 25°C
4-tert-Butylbenzenesulfonamide (CAS NO.6292-59-7) is used as an intermediate for bosentan.
Safety Information of 4-tert-Butylbenzenesulfonamide (CAS NO.6292-59-7):
Hazard Codes:Xi
Risk Statements:20/21/22
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:22-36/37/39
22:Do not breathe dust
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
Hazard Note:Irritant