Detail of "62936-56-5"

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Acute toxicity and neurotropic activity of some

Acute toxicity and neurotropic activity of some .gamma.-aminobutyric acid and pantothenic acid derivatives. Dorofeev, B. F. (Grodn. Med. Inst., Grodno, USSR). Farmakol. Toksikol. Nov. Prod. Khim. Sint., Mater. Resp. Konf., 3rd, Meeting Date 1974, 15-16. Edited by: Kuz'mitskii, B. B. Beloruss. Med. O-vo. Farmakol. Toksikol.: Minsk, USSR. (Russian) 1975. CODEN: 35ALA9. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) The i.p. acute LD50 values for mice of pantolactone (I) [599-04-2], .gamma.-[(.gamma.-hydroxybutyryl)amino]butyric acid (II) [36805-79-5], calcium pantothenate (III) [137-08-6], calcium homopantothenate (IV) [17097-76-6], lithium .gamma.-aminobutyrate (V) [31075-51-1], sodium .gamma.-[(nicotinyl)amino]butyrate (VI) [62936-56-5], .beta.-alanine (VII) [107-95-9], .gamma.-aminobutyric acid (VIII) [56-12-2], and sodium D-pantoate (IX) [60979-68-2] were 0.59, 0.86, 1.25, 1.80, 2.87, 5.00, 5.66, 6.61, and 7.60 g/kg, resp. All the compds. except III and IX prolonged hexenal sleep; VII, IV, VIII, II, VI, and I prolonged the sleep by 3.6, 2.1, 3.0, 2.6, 3.0, 2.9, and 3.7 times relative to controls. VII, VIII, II, VI, and I also prolonged chloral hydrate sleep whereas III, IV, and V were ineffective. IX had a very small effect on chloral hydrate sleep.

Acute toxicity data in the preclinical safety prognosis for the nootropic drugs piracetam and picamilon

Acute toxicity data in the preclinical safety prognosis for the nootropic drugs piracetam and picamilon. Bugaeva, L. I.; Spasov, A. A.; Verovskii, V. E.; Iezhitsa, I. N. (Institute of Pharmacology, Volgograd State Medical Academy, Volgograd 400066, Russia). Eksperimental'naya i Klinicheskaya Farmakologiya, 66(4), 43-46 (Russian) 2003 Izdatel'stvo Folium. CODEN: EKFAE9. ISSN: 0869-2092. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A comparative acute toxicity test of the nootropic drugs piracetam and picamilon was performed on rats. The study was based on the principles of integral evaluation of the drug effect upon the functional and behavioral state of animals. It was found that the conventional therapeutic index does not coincide with the actual therapeutic activity range. Piracetam and picamilon, while exhibiting significantly different toxicity, are characterized by approx. equal ranges of the therapeutic activity.Except for chemicals metioned above, 62936-56-5 and 7491-74-9 are also used. .