Detail of "63-39-8"

Reference

Effect of uridine on cellular UTP and glycogen synthesis in skeletal muscle: Stimulation of UTP formation by insulin

Effect of uridine on cellular UTP and glycogen synthesis in skeletal muscle: Stimulation of UTP formation by insulin. Haugaard, Ella S.; Frantz, Katherine B.; Haugaard, Niels (Med. Sch., Univ. Pennsylvania, Philadelphia, Pa., USA). Proc. Natl. Acad. Sci. U. S. A., 74(6), 2339-42 (English) 1977. CODEN: PNASA6. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In the rat diaphragm incubated in vitro in the absence of exogenous uridine (I) [58-96-8], the tissue content of UTP [63-39-8] and rate of glycogen [9005-79-2] synthesis decreased with time. I added to the medium increased cellular UTP and UDPG and stimulated glycogen synthesis. Insulin [9004-10-8] increased the synthesis of UTP from extracellular I. This action of insulin appeared to be due to a stimulation of phosphorylation of the nucleoside and not to an effect on transport at the concns. of I studied.

Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells

Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells. Cass, Carol E.; Lowe, Jeffrey K.; Manchak, Janet M.; Henderson, J. Frank (Cancer Res. Unit, Univ. Alberta, Edmonton, Alberta, Can.). Cancer Res., 37(9), 3314-20 (English) 1977. CODEN: CNREA8. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Mycophenolic acid (I) [24280-93-1], an inhibitor of inosinate dehydrogenase, had cytostatic and cytotoxic effects on cultured neuroblastoma cells. Proliferation was inhibited by 50% when cells were incubated with 0.07.mu.M I, and cell viability was decreased by 83% when cells were treated with 10.mu.M I for 24 h. Treatment of monolayer cultures with I decreased intracellular concns. of guanosine triphosphate [86-01-1] by 70% within 3 h, whereas cytidine triphosphate [65-47-4] and uridine triphosphate [63-39-8] concns. were significantly elevated, and adenosine triphosphate [56-65-5] concns. were increased only slightly. Redn. of cellular guanine nucleotides had differential effects on rates of macromol. synthesis: incorporation of radioactive thymidine into acid-insol. material was inhibited by I to a much greater extent than was that of adenosine and leucine. Although proliferation of neuroblastoma cells was inhibited, differentiation, as judged by formation of neuron-like processes in serum-free medium, was unaffected by decreased intracellular concns. of guanosine triphosphate.