CAS No.63-91-2,L-Phenylalanine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	63-91-2
Name:	L-Phenylalanine
Article Data:	492

Formula:	C₉H₁₁NO₂
Molecular Weight:	165.192
Synonyms:	beta-Phenylalnine, (-)-;Alanine, phenyl-;(-)-.beta.-Phenylalanine;(2S)-2-azaniumyl-3-phenyl-propanoate;(S)-Phenylalanine;alpha-Amino-beta-phenylpropionic acid, L-;(S)-alpha-Aminohydrocinnamic acid;beta-phenylalanine;L-.beta.-Phenylalanine;(2S)-2-amino-3-phenyl-propanoic acid;Phenylalamine;L-Antibiotic FN 1636;2-Amino-3-phenylpropionic acid, L-;Phenylalanine (USP);Hydrocinnamic acid, alpha-amino-;(L)-Phenylalanine;Alanine, phenyl-, L-;L-Phenylalanine (JP14);
EINECS:	200-568-1
Density:	1.201 g/cm³
Melting Point:	270-275 °C (dec.)(lit.)
Boiling Point:	307.5 °C at 760 mmHg
Flash Point:	139.8 °C
Solubility:	water: 1-5 g/100 mL at 25 °C
Appearance:	white crystalline powder
Hazard Symbols:	C
Risk Codes:	36/37/38-34
Safety:	22-24/25-37/39-45-36/37/39-27-26
PSA:	63.32000
LogP:	1.34130

Synthetic route

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With ammonium bicarbonate; water In dichloromethane for 48h; α-chymotrypsin;	100%
With sodium hydroxide In water; ethyl acetate pH=9 - 10;	93%
at 25℃; for 0.833333h; enzyme alcalase from Bacillus licheniforms; pH 8.2;

: 1161-13-3
N-Cbz-L-Phe

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With cell extract of Sphingomonas paucimobilis SC 16113 In water at 42℃; for 20h; Enzymatic reaction;	100%
With hydrogen In ethanol for 0.5h;	100%
With palladium on activated charcoal In methanol; ethyl acetate	99%

: 3081-24-1
H-Phe-OEt

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With ammonium bicarbonate; water In dichloromethane for 36h; α-chymotrypsin;	100%
With Tris buffer; water at 50℃; Rate constant;
With human valacyclovirase; water at 37℃; pH=7.4; Kinetics; Time; HEPES buffer; Enzymatic reaction;

: 439912-45-5
((prop-2-yn-1-yloxy)carbonyl)-L-phenylalanine

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With resin bound tetrathiomolybdate In methanol at 28℃; for 1.5h; ultrasonic bath;	100%

: 156-06-9
2-oxo-3-(phenyl)propionic acid

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With formate dehydrogenase; NAD; ammonium formate at 30℃; for 24h; PheDH;	99%
With A-(modified B6)-B-<ω-amino(ethylamino)>-β-cyclodextrin In water at 30℃; for 5h; pH 8.0 (phosphate buffer); Yield given;
With formate dehydrogenase; NAD; ammonium formate at 30℃; for 24h; Mechanism; buffer (pH 8.5); other oxo-acids; PheDH;

: 108321-83-1
phenylalanine amide hydrochloride

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With pyridoxal 5'-phosphate monohydrate; cobalt(II) chloride In aq. buffer at 40℃; for 4h; pH=7.0; Enzymatic reaction;	99%

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With pepsin immobilized on terephthalaldehyde functionalized chitosan magnetic nanoparticle In acetonitrile at 20℃; for 48h; pH=2;	98%
With hydrogenchloride
With hydrogen bromide

: 620-76-8
phenylpyruvate-

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With ammonium formate; tris hydrochloride; nicotinamide adenine dinucleotide; formate dehydrogenase; phenylalanine dehydrogenase In water at 30℃; for 24h;	98%
With ammonium formate; tris hydrochloride; nicotinamide adenine dinucleotide; phenylalanine and formate dehydrogenase In water at 30℃; for 24h; Equilibrium constant; pH = 8.5;	98%
With L-glutamic acid; pyridoxal 5'-phosphate In water at 40℃; for 12h; E.coli Aspartate transaminase, pH 8;	84%
With L-glutamic acid; E.coli Aspartate transaminase; pyridoxal 5'-phosphate at 40℃; for 12h; enzyme kinetics; pH 8; Miachaelis constant (Km); maximum velocity constant (vmax); further α-keto acids;	84%
With L-glutamine; human glutamine transaminase K at 37℃; pH=7.4; aq. phosphate buffer; Enzymatic reaction;

: 631921-67-0
((S)-1-Cyano-2-phenyl-ethyl)-carbamic acid methyl ester

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With hydrogenchloride In water for 7h; Heating;	98%

: 1202-31-9
(S)-2-hydrazinyl-3-phenylpropanoic acid

: 63-91-2
L-phenylalanine

Conditions

Conditions	Yield
With hydrogen; nickel In water; acetic acid under 25857.4 Torr;	97%

Raw Materials

583-47-1

133-99-3

Downstream Products

949-99-5

124-38-9

10030-31-6

123-32-0

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History

The genetic codon for phenylalanine was first discovered by J. Heinrich Matthaei and Marshall W. Nirenberg in 1961. This discovery helped to establish the nature of the coding relationship that links information stored in genomic nucleic acid with protein expression in the living cell.

Consensus Reports

Reported in EPA TSCA Inventory.

Specification

1. Introduction of L-Phenylalanine

L-Phenylalanine, with the IUPAC Name of (2S)-2-amino-3-phenylpropanoic acid, is one kind of white crystalline powder. This chemical is incompatible with strong oxidizing agents, and it belongs to the Product Categories which include Food and Feed Additive;Amino ACIDS SERIES;API intermediates;Phenylalanine [Phe, F];Amino Acids and Derivatives;Amino Acids 13C, 2H, 15N;alpha-Amino Acids;Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;Amino Acids & Derivatives.

2. Properties of L-Phenylalanine

L-Phenylalanine has the following datas: (1)Index of Refraction: 1.576; (2)Molar Refractivity: 45.49 cm³; (3)Molar Volume: 137.4 cm³; (4)Polarizability: 18.03×10-24cm³; (5)Surface Tension: 53.5 dyne/cm; (6)Density: 1.201 g/cm³; (7)Flash Point: 139.8 °C; (8)Enthalpy of Vaporization: 57.87 kJ/mol; (9)Melting Point: 270-275 °C (dec.)(lit.); (10)Boiling Point: 307.5 °C at 760 mmHg; (11)Vapour Pressure: 0.000313 mmHg at 25°C; (12)Water Solubility: 1-5 g/100 mL at 25 oC.

3. Structure Descriptors of L-Phenylalanine

You could convert the following datas into the molecular structure:
InChI:InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChIKey:InChIKey=COLNVLDHVKWLRT-QMMMGPOBSA-N
Smiles:c1(C[C@@H](C(O)=O)N)ccccc1

4. Toxicity of L-Phenylalanine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 1322mg/kg (1322mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
rat	LD50	intraperitoneal	5287mg/kg (5287mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.

5. Safety Information of L-Phenylalanine

Mildly toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:

C: Corrosive
Risk Statements: 36/37/38-34
36/37/38: Irritating to eyes, respiratory system and skin
34: Causes burns
Safety Statements: 22-24/25-37/39-45-36/37/39-27-26
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
37/39: Wear suitable gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
27: Take off immediately all contaminated clothing
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
F 10: Keep under argon
WGK Germany: 3

6. Use of L-Phenylalanine

L-Phenylalanine is an electrically-neutral amino acid, one of the twenty common amino acids used to biochemically form proteins, coded for by DNA.