Reference

The effect of

The effect of .beta.-adrenergic substances on exocrine pancreatic function. Studies in the isolated perfused cat pancreas. Heidbreder, E.; Sieber, P.; Heidland, A. (Med. Universitaetsklin. Wuerzburg, Wuerzburg, Ger.). Res. Exp. Med., 171(1), 79-92 (German) 1977. CODEN: REXMAS. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The .beta.-sympathomimetics, isoproterenol sulfate [299-95-6], orciprenaline sulfate [5874-97-5], salbutamol [18559-94-9], fenoterol-HBr [1944-12-3], and terbutaline sulfate [23031-32-5], increased protein and enzyme secretion by isolated cat pancreas but did not affect the excretion of Ca into the juice or the rate of vol. output. The sympatholytics, phentolamine-HCl [73-05-2], phenoxybenzamine-HCl [63-92-3], L-propranolol-HCl [4199-10-4], D-propranolol-HCl [13071-11-9], prindolol [13523-86-9], oxprenolol-HCl [6452-73-9], practolol [6673-35-4], and butoxamine-HCl [5696-15-1], inhibited pancreatic enzyme and protein secretion. Tetracaine-HCl [136-47-0], atropine sulfate [55-48-1], and hemicholinium [16478-59-4] also inhibited pancreatic protein and enzyme secretion. Pretreatment with reserpine or 6-hydroxydopamine did not inhibit the pancreas response to the sympathomimetics, indicating that they influence pancreatic protein and enzyme secretion in a cholinergic way.

Selectivity of blocking agents for pre- and postsynaptic

Selectivity of blocking agents for pre- and postsynaptic .alpha.-adrenoceptors. Doxey, J. C.; Smith, C. F. C.; Walker, Julie M. (Pharm. Div., Reckitt Colman, Hull, Engl.). Br. J. Pharmacol., 60(1), 91-6 (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Low frequency (0.1 Hz) elec. stimulation of isolated rat vas deferens produced regular contractions that were inhibited by low concns. of clonidine-HCl [4205-91-8]. Clonidine inhibition was presynaptic in origin and involved .alpha.-adrenoceptors. Yohimbine-HCl [65-19-0] (100 ng/mL) and phentolamine mesylate [65-28-1] (100 ng/mL) were more potent in blocking presynaptic than postsynaptic .alpha.-adrenoceptors. Phenoxybenzamine-HCl [63-92-3] (100 ng/mL) and prazosin-HCl [19237-84-4] (10 ng/mL) blocked postsynaptic .alpha.-adrenoceptors preferentially.In this article, certain chemicals are used. One of their cas registry numbers is 32808-09-6 Presynaptic and postsynaptic .alpha.-adrenoceptors differ in their sensitivity to .alpha.-adrenoceptor antagonists. .