Reference

Nicotinonitriles and nicotinamides and intermediates

Nicotinonitriles and nicotinamides and intermediates. Gelotte, Karl Olaf; Singh, Baldev (Sterling Drug, Inc., USA). Eur. Pat. Appl. EP 95152 A1 30 Nov 1983, 20 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW.Several substances with their cas registry numbers 89055-68-5 and 6304-16-1 may be metioned in this study. CLASS: IC: C07D213-50; C07D213-85; C07D213-82. ICA: A61K031-44. APPLICATION: EP 83-104984 19 May 1983. PRIORITY: US 82-381162 24 May 1982; US 82-381062 24 May 1982; US 83-471961 3 Mar 1983. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Pyridylmethyl alkyl ketones were treated with trialkyl orthoformates to yield 1-pyridylvinyl ketones I (R and R1 are alkyl, R2 and R3 are H or alkyl). 4-Acetonylpyridine was stirred with HC(OEt)3, Ac2O, and HOAc to yield 4-ethoxy-3-(4-pyridyl)-3-buten-2-one, and the latter was heated with NCCH2CONH2 and NaOMe in MeOH to give nicotinonitrile deriv. II. .