CAS No.63074-07-7,Methanone,1-piperazinyl(tetrahydro-2-furanyl)- Suppliers

Detail of "63074-07-7"

CAS Number:

63074-07-7

Name:

Methanone,1-piperazinyl(tetrahydro-2-furanyl)-

Superlist Name:

1-(Tetrahydro-2-furoyl)piperazine

Molecular Structure:

Formula:

C₉H₁₆N₂O₂

Molecular Weight:

184.2355

Synonyms:

Piperazine,1-[(tetrahydro-2-furanyl)carbonyl]- (9CI);(Piperazin-1-yl)(tetrahydrofuran-2-yl)methanone;1-(Tetrahydrofuran-2-carbonyl)piperazine;1-(Tetrahydrofuran-2-ylcarbonyl)piperazine;1-[(2,3,4,5-Tetrahydrofuran-2-yl)carbonyl]piperazine;4-[(Tetrahydrofuran-2-yl)carbonyl]piperazine;N-(Tetrahydro-2-furoyl)piperazine;

Density:

1.147 g/cm³

Boiling Point:

356.8 °C at 760 mmHg

Flash Point:

169.6 °C

Appearance:

colorless to yellow viscous liquid

Hazard Symbols:

Risk Codes:

36/37/38

Safety:

37/39-26 Details

Reference

2-[4-(2-Furoyl)-1-piperazin-1-yl]-4-amino-6,7-dimethylquinazoline-contai ning antihypertension drugs: 2-[4-(2-Furoyl)-1-piperazin-1-yl]-4-amino-6,7-dimethylquinazoline-contai ning antihypertension drugs. Winn, Martin; Kyncl, Jaroslav; Dunnigan, Daniel Ambrose; Jones, Peter Hadley (Abbott Laboratories, USA). Ger. Offen. DE 2646186 28 Apr 1977, 22 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D405-14. PRIORITY: US 75-621980 14 Oct 1975. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 2-[4-(2-Furoyl)-1-piperazinyl]-4-amino-6,7-dimethylquinazoline derivs. with good H2O soly. are prepd. and show antihypertensive activity. For example, 39 g N-(2-furoyl)piperazine-HBr [63074-06-6] was hydrogenated and then treated with NaOH to give 22.5 g N-(tetrahydro-2-furoyl)piperazine [63074-07-7]. This compd. (10.8 g) was refluxed with 7 g 2-chloro-4-amino-6,7-dimethoxyquinazoline [23680-84-4] to give 8.12 g 2-[4-(tetrahydro-2-furoyl)-1-piperazinyl]-4-amino-6,7-dimethoxyquinazoli ne-HCl (I) [63074-08-8]. I had water soly. of 590 mg/mL.Several reagents such as 63074-09-9 is used here. An i.p. dose of 30 mg I/kg decreased the blood pressure 20-60% for >24 h in spontaneous hypertonic rats. A 3-10 mg/kg oral dose gave a .ltoreq.40% decreaase. .

Process for the manufacture of terazosin hydrochloride dihydrate: Process for the manufacture of terazosin hydrochloride dihydrate. Murthy, Keshava; Brownell, Lori (Acic (Canada) Inc., Can.). Can. Pat. Appl. CA 2150985 AA 6 Dec 1996, 7 pp. (English). (Canada).Several substances with their cas registry numbers 63074-07-7 and 157459-53-5 may be metioned in this study. CODEN: CPXXEB. CLASS: ICM: C07D405-14. APPLICATION: CA 1995-2150985 5 Jun 1995. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 A process for producing terazosin hydrochloride dihydrate comprising introducing a molar equivalent of aq. hydrochloric acid to a suspension of terazosin free base in water at ambient temp. and stirring the resulting soln. to crystallize terazosin hydrochloride dihydrate therefrom at ambient temp. .

Detail of "63074-07-7"

Methanone,1-piperazinyl(tetrahydro-2-furanyl)-

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CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

CAS No.63074-07-7 1-(Tetrahydro-2-furoyl)piperazine

Reference