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CAS No.: | 63095-51-2 |
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Name: | (R)-4-Propyldihydrofuran-2(3H)-one |
Article Data: | 48 |
Molecular Structure: | |
Formula: | C7H12O2 |
Molecular Weight: | 128.171 |
Synonyms: | (S)-3-propylbutyrolactone;.(R)-4-propyl-dihydro-furan-2-one; |
Density: | 0.983±0.06 g/cm3(Predicted) |
Boiling Point: | 226.3±8.0 °C(Predicted) |
PSA: | 26.30000 |
LogP: | 1.34960 |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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In toluene at 120℃; for 2h; Time; | 99% |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With hydrogenchloride In water at 75℃; for 1h; Reagent/catalyst; Solvent; | 95.6% |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With palladium 10% on activated carbon; hydrogen In methanol under 750.075 - 1500.15 Torr; Autoclave; | 95% |
(4R)-4-allyldihydrofuran-2(3H)-one
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With palladium 10% on activated carbon; hydrogen In methanol at 35℃; for 6h; enantioselective reaction; | 95% |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With sulfuric acid In water at 100℃; for 6h; | 95% |
4-propyl-5H-furan-2-one
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With bis(η5-cyclopentadienyl)ruthenium; (R,R)-(+)-2,2'-isopropylidene bis(4-isopropyl-2-oxazoline); hydrogen In methanol at 50℃; under 15001.5 Torr; Temperature; Pressure; Solvent; Reagent/catalyst; Autoclave; | 93% |
With water; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); copper(l) chloride; sodium t-butanolate In toluene; tert-butyl alcohol at 0 - 30℃; Inert atmosphere; | 79.63% |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 9000.9 Torr 2: sodium hydroxide / water / 2 h / 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon; hydrogen / ethanol / 9 h / 20 °C / 225.02 - 375.04 Torr / Large scale 2: sodium hydroxide / ethanol / 1 h / 20 °C / Large scale 3: 0.5 h / 20 °C / Large scale 4: hydrogenchloride / water / 3 h / 20 - 60 °C / Large scale View Scheme |
cis-4-propyl-5-p-tolylthio-4,5-dihydrofuran-2(3H)-one
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene at 90 - 100℃; for 0.5h; | 92% |
n-propylmagnesium bromide
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With [2,2]bipyridinyl; copper(l) iodide; lithium methanolate In tetrahydrofuran at 0℃; for 24h; Reagent/catalyst; Solvent; | 92% |
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With hydrogenchloride In water at 20 - 60℃; for 3h; Large scale; | 92% |
(2R)-2-propyl-3-(1,3-dithian-2-ylidene)propanol
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
Conditions | Yield |
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With toluene-4-sulfonic acid In dichloromethane for 1h; Ambient temperature; | 90% |