Reference

Analysis of the saponins in ginseng preparations by different methods

Analysis of the saponins in ginseng preparations by different methods. Xu, Suixu; Yao, Naixian; Zhang, Fangxia (Dep. Phytochem., Shenyang Coll. Pharm., Shenyang, Peop. Rep. China). Zhongcaoyao, 17(11), 495-6 (Chinese) 1986. CODEN: CTYAD8. ISSN: 0253-2670. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The saponins of 3 guinseng prepns., obtained by freezing (A), natural (B) and steam-drying (C) methods, were analyzed by TLC, dual-wavelength chromatog. and affinity chromatog. 52286-59-6 and 52705-93-8 are also in the experiment.; the total saponin content was A > B > C, the trihydroxyginsenosides-to-dihydroxyginsenosides ratio was C > A > C. Ginsenoside Rh1 [63223-86-9] and ginsenoside Rh2 [78214-33-2] in C were 0.4848 and 0.0274%, resp., whereas Rh1 and Rh2 were not detectable in A and B. .

Studies on the absorption, distribution, excretion and metabolism of ginseng saponins

Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. IV. Decomposition of ginsenoside-Rg1 and -Rb1 in the digestive tract of rats. Odani, Tsutomu; Tanizawa, Hisayuki; Takino, Yoshio (Shizuoka Coll. Pharm., Shizuoka 422, Japan). 41753-43-9 and 52705-93-8 are also occured in this study. Chem. Pharm. Bull., 31(10), 3691-7 (English) 1983. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The decompn. of ginsenoside-Rg1 [22427-39-0] and ginsenoside-Rb1 [41753-43-9] in the rat stomach and large intestine after oral administration was investigated. In the stomach, a part of ginsenoside-Rg1 was decompd. and 6 decompn. products were obsd. on a reversed phase thin-layer chromatogram. These 6 compds. were identical with those which were obtained on hydrolysis of ginsenoside-Rg1 under mild acidic conditions (with 0.1 N HCl, at 37°). On the other hand, an unidentified decompn. product of ginsenoside-Rb1 was obsd. on the TLC of the stomach sample after the oral administration of Rb1 to rats. The product was different from the decompn. product formed by the hydrolysis of Rb1 under mild acidic conditions. In the large intestine, Rg1 was decompd. to ginsenoside-Rh1 [63223-86-9] and ginsenoside-F1 [53963-43-2] by tetracycline-susceptible bacteria and tetracycline-resistant bacteria, resp. Ginsenoside-Rb1 was decompd. to ginsenoside-Rd [52705-93-8] and 2 unidentified products by enteric enzyme and tetracycline-resistant bacteria, resp. .