Reference

1-Methyl-2-(pyridyloxymethyl)-5-nitroimidazoles

1-Methyl-2-(pyridyloxymethyl)-5-nitroimidazoles. Winkelmann, Erhardt; Raether, Wolfgang (Hoechst A.-G.In this study，61800-08-6 is also used., Ger.). Ger. Offen. DE 2522176 25 Nov 1976, 9 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D233-64. APPLICATION: DE 75-2522176 17 May 1975. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 27 The title compds. (I; R = 2-nitro-3-pyridinyl, 3-nitro-2-pyridinyl, 5-nitro-2-pyridinyl, 3-nitro-4-pyridinyl), useful as protozoacides (no data), are prepd. from 2-(chloromethyl)-1-methyl-5-nitroimidazole (II) and nitropyridinols or from 1-methyl-5-nitro-2-imidazolemethanol and halonitropyridines. Thus, condensation of II with 2-nitro-3-pyridinol in MeCONMe2 in presence of K2CO3 at 25.degree. and 30 min at 40-50.degree. gives 77% I (R = 2-nitro-3-pyridinyl). .

Oligocyclization of 2-(hydroxymethyl)pyrroles with electron-withdrawing groups at b-positions: formation and structural elucidation of porphyrinogens and hexaphyrinogens

Oligocyclization of 2-(hydroxymethyl)pyrroles with electron-withdrawing groups at b-positions: formation and structural elucidation of porphyrinogens and hexaphyrinogens. Uno, Hidemitsu; Inoue, Kentarou; Inoue, Takashi; Ono, Noboru ( Division of Synthesis and Analysis, Department of Molecular Science, Integrated Center for Sciences (INCS), Ehime University, and CREST, Japan Science Technology Corporation (JST), Matsuyama 790-8577, Japan). Organic & Biomolecular Chemistry, 1(21), 3857-3865 (English) 2003 Royal Society of Chemistry. CODEN: OBCRAK. ISSN: 1477-0520. DOCUMENT TYPE: Journal CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 75 Acid-catalyzed oligomerization of 2-(hydroxymethyl)pyrroles bearing C6F5, 2,6-Cl2C6H3, CF3 and CO2Et groups at b-positions was examd. 289882-85-5 and 6332-56-5 are also in the experiment. The reaction of Et pyrrole-3-carboxylates gave a mixt. of oligomers and type I isomers of porphyrinogens and hexaphyrinogens were isolated when the other b-substituents were sufficiently bulky, for example, mesityl, 2,6-Cl2C6H3 and C6F5 groups. On the other hand, the pyrroles having other electron-withdrawing groups afforded porphyrinogens as the only isolable products. .