CAS No.6339-87-3,2-Thiophenesulfonamide Suppliers,MSDS download

Detail of "6339-87-3"

CAS Number:

6339-87-3

Name:

Superlist Name:

Thiophene-2-sulfonamide

Molecular Structure:

Formula:

C₄H₅NO₂S₂

Molecular Weight:

163.22

Synonyms:

Thiophene-2-sulfonamide;NSC 42521;Sulfamido-2 thiophene;

Density:

1.513 g/cm³

Melting Point:

146-148 °C

Boiling Point:

338.1 °C at 760 mmHg

Flash Point:

158.3 °C

Hazard Symbols:

Tryptamine-based human b3-adrenergic receptor agonists: Tryptamine-based human b3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring. Mizuno, Kazuhiro; Sawa, Masaaki; Harada, Hiroshi; Tateishi, Hirotaka; Oue, Mayumi; Tsujiuchi, Hiroshi; Furutani, Yasuji; Kato, Shiro ( Chemistry Research Laboratories, Ltd, Dainippon Pharmaceutical Co., Enoki, Suita 564-0053, Japan). Bioorganic & Medicinal Chemistry Letters, 14(24), 5959-5962 (English) 2004 Elsevier B.V. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 A series of tryptamine-based 2-thiophenesulfonamide derivs. were prepd. and their agonistic activity for the b-adrenergic receptors (ARs) was evaluated. 2-Thiophenesulfonamide I, contg. 7-methanesulfonyloxy tryptamine, was found to be a highly potent b3-AR agonist (EC50 = 0.21 nM, IA = 97%) with excellent selectivity for the b3-AR over the b1- and b2-ARs (210- and 86-fold, resp.).Except for chemicals metioned above, 776302-26-2 and 776301-44-1 are also used. .

Comparison between two classes of selective EP3 antagonists and their biological activities: All Rights Reserved. Comparison between two classes of selective EP3 antagonists and their biological activities. Belley, Michel; Chan, Chi Chung; Gareau, Yves; Gallant, Michel; Juteau, Helene; Houde, Karine; Lachance, Nicolas; Labelle, Marc; Sawyer, Nicole; Tremblay, Nathalie; Lamontagne, Sonia; Carriere, Marie-Claude; Denis, Danielle; Greig, Gillian M.; Slipetz, Deborah; Gordon, Robert; Chauret, Nathalie; Li, Chun; Zamboni, Robert J.; Metters, Kathleen M. (Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, QC H9R 4P8, Can.). Bioorganic & Medicinal Chemistry Letters, 16(21), 5639-5642 (English) 2006 Elsevier Ltd. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Two different series of very potent and selective EP3 antagonists have been reported: a novel series of ortho-substituted cinnamic acids [M. Belley et al, 2005] and the acylsulfonamides of ortho-(arylmethyl)cinnamates [H. Juteau, et al, 2001 and 1977]. The structural differences between the two series, along with their biol. activity in vivo, in vitro, and metab., are analyzed. There are some commonly used reagents like 915147-19-2 in this article. Some of those compds., including hybrids contg. the best structural features of both series, possess Ki as low as 0.6 nM on the EP3 receptor. .

Detail of "6339-87-3"